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Application of composition of donkey-hide gelatin and new donkey-hide gelatin in preparing antioxidant drug

A composition and anti-oxidation technology, which is applied in the direction of drug combination, medical preparations containing active ingredients, anti-toxic agents, etc., can solve the problems of undisclosed application of donkey-hide gelatin and new donkey-hide gelatin composition, limited anti-oxidation effect of donkey-hide gelatin, etc.

Pending Publication Date: 2020-02-28
山东福牌阿胶股份有限公司
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0005] It is recorded in the prior art that donkey-hide gelatin has anti-oxidation effect, refer to the paper (Cao Feiwei. Antioxidant effect and mechanism research of donkey-hide gelatin cake and its main raw material donkey-hide gelatin [D]. Zhejiang University, 2019.), but in actual use, donkey-hide gelatin The antioxidant effect of Ejiao is limited, and the application of donkey-hide gelatin and new donkey-hide gelatin compositions in the preparation of antioxidant drugs is not disclosed in the prior art

Method used

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  • Application of composition of donkey-hide gelatin and new donkey-hide gelatin in preparing antioxidant drug
  • Application of composition of donkey-hide gelatin and new donkey-hide gelatin in preparing antioxidant drug

Examples

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Embodiment

[0016] Example: Antioxidant activity evaluation experiment of donkey-hide gelatin and new donkey-hide gelatin composition

[0017] The experimental method used in this embodiment is:

[0018] Using 24-hour-developed fluorescent zebrafish as the experimental animal, use 1 mg / mL pronase to remove the egg membrane of the outer layer of the embryo. The embryos that had been removed from the egg membrane were randomly assigned, and each group of experiments consisted of 10 embryos, and two replicate wells were set up at the same time. Each group of experiments was repeated three times, and the experimental results were averaged. All the above embryos were placed in a constant temperature incubator at 28.5°C, treated with each experimental solution in Table 1 for 24 hours, anesthetized the zebrafish with ethyl m-aminobenzoate methanesulfonate (MS222), and observed under a fluorescent microscope Photograph. The number of fluorescent spots on the skin of zebrafish was counted using ...

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Abstract

The invention discloses an application of a composition of donkey-hide gelatin and new donkey-hide gelatin in preparing an antioxidant drug. The experimental method adopts skin fluorescent transgeniczebrafish developing 24hpf (hour post fertilization) as an experimental animal, the drug is incubated with an embryo for 24h, and after the incubation is finished, the change of skin fluorescence number is observed under a fluorescence microscope. According to experiments, the composition of the donkey-hide gelatin and the new donkey-hide gelatin has a reversing effect on metronidazole-induced reduction in the number of skin fluorescence spots of the zebrafish, and the composition of the donkey-hide gelatin and the new donkey-hide gelatin has antioxidant activity under the conditions of appropriate acting concentration and proportioning. Experiments show that the composition of the donkey-hide gelatin and the new donkey-hide gelatin can be used for preparing the antioxidant drug; and especially the composition can be used for preparing drugs for cell oxidation-related diseases caused by using metronidazole.

Description

technical field [0001] This application relates to the new application of donkey-hide gelatin composition, in particular to the application of a composition of donkey-hide gelatin and new donkey-hide gelatin in the preparation of antioxidant drugs. Background technique [0002] Free radicals are particles with unpaired electrons. Because it has a single number of electrons, it is very unstable and highly chemically reactive, and it is easy to react with the surrounding molecules, turning stable molecules into free radicals. So repeated, it will generate a large number of free radicals. In general, life is inseparable from free radical activity. Our body moves from inside to outside every moment, burning energy every moment, and the porters responsible for transferring energy are free radicals. When these free radicals, which help in energy conversion, are enclosed in cells and cannot run around, they are harmless to life. But if the activities of free radicals get out of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/36A61P39/06
CPCA61K35/36A61P39/06A61K2300/00
Inventor 杨铧杨福安武勇孔繁惠
Owner 山东福牌阿胶股份有限公司