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A technology of gold nanorods and chloroauric acid, applied in the direction of nanotechnology, nanotechnology, metal processing equipment, etc., can solve the problems of controllable synthesis of gold nanorods, cytotoxicity, etc., and achieve long reaction cycle and no cell Effects of toxicity and mild reaction conditions
Pending Publication Date: 2020-02-28
QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
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However, CTAB has certain cytotoxicity, and the nanorods prepared by using CTAB need to be further processed before they can be used in medicine.
[0004] It has been discovered that the diversity of self-assembled structures of block copolymers can be used to prepare gold nanomaterials, but the controllable synthesis of gold nanorods has not yet been reported.
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Embodiment 1
[0030] Embodiment 1, the preparation method of gold nanorods in the present embodiment is accomplished through the following steps:
[0031] (1) Prepare a Pluronic P123 sample with a concentration of 0.5w.t.%. Prepare 35mM LiOH aqueous solution for later use.
[0032] (2) Take 4 mL of Pluronic P123 aqueous solution with a concentration of 0.5w.t.%, add 4 μL of LiOH aqueous solution prepared above, mix well and measure the pH value to be 7. Heat in a constant temperature water bath for 30 min, and set the temperature at 40°C.
[0033] (3) Quickly inject 0.4mL tetrachloroauric acid solution with a concentration of 1.2mM into the above solution with a pipette gun, mix with a vortex mixer for 10 seconds, and continue heating at 40°C until the reaction is complete, and the reaction time is 3 hours . The average particle size of the obtained gold nanorods is 15.4nm×34.6nm, which is equivalent to the particle size of the gold nanorods prepared by the traditional method, but the re...
Embodiment 2
[0034] Embodiment 2, the preparation method of gold nanorods in the present embodiment is accomplished through the following steps:
[0035] (1) Prepare a Pluronic P123 sample with a concentration of 0.5w.t.%, and prepare a 35mM LiOH aqueous solution for later use.
[0036] (2) Take 4 mL of Pluronic P123 aqueous solution with a concentration of 0.5w.t.%, add 4 μL of LiOH aqueous solution prepared above, mix well and measure the pH value to be 7. Heat in a constant temperature water bath for 30 min, and set the temperature at 40°C.
[0037] (3) Quickly inject 0.4mL of sodium chloroaurate solution with a concentration of 1.2mM into the above solution with a pipette gun, mix with a vortex mixer for 10 seconds, and continue heating at 40°C until the reaction is complete, and the reaction time is 3 hours . The average particle size of the obtained gold nanorods is 15.2nm×36.5nm, which is equivalent to the particle size of the gold nanorods prepared by the traditional method, but ...
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Abstract
The invention discloses a preparation method for gold nanorods, and belongs to the field of synthetic preparation of metal nanomaterials. The method comprises the steps that an aqueous solution of a polyoxyethylene-polypropylene oxide-polyoxyethylene amphiphilic block copolymer is prepared and then pre-heated, a chloroauric acid solution with the same temperature is quickly injected, even mixing is conducted, water-bath heating is conducted, and after a reaction is completed, a mixture is naturally cooled to the room temperature. According to the preparation method, by regulating and controlling the self-assembling process of the amphiphilic block copolymer, the rodlike micelle morphology is formed and taken as a template to regulate and control growth of gold nanoparticles, and thus the gold nanorod particles are obtained. Meanwhile, under the alkaline condition, hydrophobic interaction between the amphiphilic block copolymer Pluronic and nanogold is enhanced, the Pluronic is adsorbedon the surface of the nanogold, and the gold nanorods can be stabilized in the solution for several months and do not agglomerate. The gold nanorod particles existing in the solution do not have cytotoxicity and can be used for biological substance detection and bioaffinity drug vectors.
Description
technical field [0001] The invention belongs to the field of synthesis and preparation of metal nanomaterials, and relates to a method for synthesizing rod-shaped gold nanoparticles by using an amphiphilic block copolymer. Background technique [0002] Due to their unique physical and chemical properties, nanoparticles have attracted great attention from scientists. Noble metal nanorods such as gold nanorods have excellent properties that other materials do not. Gold nanorods have excellent spectroscopic and electrical properties, such as photothermal effect and unique near-infrared absorption peaks. Among them, gold nanorods have been successfully used in photothermal therapy, directional drug delivery and catalysts due to their excellent optical and structural properties. Photothermal therapy is expected to become a low-damage and highly effective cancer treatment method. Heavy metal nanorods are being extensively and intensively studied in the fields of medicine and ma...
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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B22F1/00B82Y30/00B82Y40/00
CPCB22F9/24B82Y30/00B82Y40/00B22F1/07B22F1/054
Inventor 寿庆辉梁向峰刘会洲郭晨孙玲玲李敏
Owner QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
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