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A kind of preparation method of fluorine-containing polyacrylic acid copolymer antibacterial composite material and obtained product and application

A kind of copolymer and polyacrylic acid technology, applied in the fields of botanical equipment and methods, chemicals for biological control, applications, etc., can solve the problems of low surface energy of fluoropolymers, difficult to interact with substrates, and increase the difficulty of application. , to achieve the effect of preventing the reduction of sterilization efficiency, high sample yield and simple operation

Active Publication Date: 2022-03-18
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the hydrophobic and oleophobic characteristics of fluoropolymers, it is difficult to disperse in solvents alone as an antibacterial material, which increases the difficulty of its application; moreover, the surface energy of fluoropolymers is relatively low, and it is not easy to interact with the substrate, so a stable coating cannot be obtained

Method used

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  • A kind of preparation method of fluorine-containing polyacrylic acid copolymer antibacterial composite material and obtained product and application
  • A kind of preparation method of fluorine-containing polyacrylic acid copolymer antibacterial composite material and obtained product and application
  • A kind of preparation method of fluorine-containing polyacrylic acid copolymer antibacterial composite material and obtained product and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] (1) Synthesis of fluorine-containing polyacrylic acid copolymer

[0052] Monomer acrylic acid and 1H,1H,2H,2H - ethyl perfluorodecyl acrylate and azobisisobutyronitrile are dissolved with THF, the solid content of the resulting solution is 10wt%, and the solution is dissolved in N 2 Under protection, the temperature was raised to 65°C, and the temperature was kept for 8 hours. The obtained precipitate was washed three times with n-hexane, and dried for later use.

[0053] (2) Fluorine-containing polyacrylic acid copolymer cross-linked in water

[0054] Dissolve fluorine-containing polyacrylic acid copolymer in ultrapure water to prepare a solution with a concentration of 25wt%, add an aziridine crosslinking agent with a carboxyl molar mass of 5% to the solution, stir at room temperature for 1 hour, and place the solution in dialysis Dialyze the bag to remove excess crosslinker.

[0055] (3) Slightly cross-linked fluorine-containing polyacrylic acid copolymer compoun...

Embodiment 2

[0060] Prepare fluorine-containing polyacrylic acid copolymer antibacterial composite material according to the method of Example 1, the difference is: in step (1), it is prepared by RAFT polymerization, and the specific experimental steps are: acrylic acid and 1H,1H,2H,2H -perfluorodecyl ethyl acrylate, azobisisobutyronitrile and trithioester are dissolved in THF, the solid content of the solution is 10wt%, and the solution is dissolved in N 2 Under protection, the temperature was raised to 65°C, and the temperature was kept for 24 hours. The obtained precipitate was washed three times with n-hexane, and dried for later use. According to the plate test, no live bacteria were detected on the surface of the film, indicating that the film has good anti-bacterial adhesion and bactericidal effects. The antibacterial composite material has no cytotoxicity as detected by the cytotoxicity test.

Embodiment 3

[0062] Prepare fluorine-containing polyacrylic acid copolymer antibacterial composite material according to the method of Example 1, the difference is: in step (1), the used 1H,1H,2H,2H - Ethyl perfluorodecyl acrylate is replaced by perfluorooctylethyl methacrylate, the molar ratio of acrylic acid to perfluorooctylethyl methacrylate is 50:1. After the plate test, the anti-adhesion test film surface detected 10 CFU / cm 2 Live bacteria, no live bacteria were detected on the surface of the film in the bactericidal experiment, indicating that the film has good anti-bacterial adhesion and bactericidal effects. The antibacterial composite material has no cytotoxicity as detected by the cytotoxicity test.

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Abstract

The invention discloses a preparation method of a fluorine-containing polyacrylic acid copolymer antibacterial composite material and the resulting product and application. The fluorine-free acrylic monomer and the fluorine-containing acrylate monomer are polymerized to form a fluorine-containing polyacrylic copolymer, and then The fluorine-containing polyacrylic acid copolymer is appropriately cross-linked to form a copolymer with a certain degree of cross-linking, and finally the cross-linked copolymer is compounded with an antibacterial agent to form a composite antibacterial material. The reaction conditions of the method of the present invention are relatively mild, the operation is simple, and the sample yield is high. The obtained antibacterial composite material has anti-bacterial adhesion, sterilization, pH responsiveness and fluorescence characteristics, and can be made into a thin film or coating for the surface of the product, which can not only prevent The adhesion of bacteria, dust, etc., can also efficiently kill the bacteria attached to it, prevent the reduction of sterilization efficiency caused by the adhesion of dead bacteria or live bacteria, and have good antifouling and antibacterial effects. , sanitation, food and other fields have good application prospects.

Description

technical field [0001] The invention relates to a preparation method of a fluorine-containing polyacrylic acid copolymer antibacterial composite material, the obtained product and its application, and belongs to the technical field of polymer antibacterial materials. Background technique [0002] Bacterial infection involves many key fields such as medical hygiene, food safety, biomedical equipment, etc., seriously threatens human health, and even causes death. It has become the largest public health problem in the world, with millions of reports reported every year. Especially in hospitals, through the contact cycle of various surfaces-medical staff-patients, infection will spread rapidly in medical institutions, and it is difficult to prevent and eradicate. It is estimated that nearly half of the nosocomial infections received by hospitalized patients are related to various surfaces. related to bacterial contamination. Previous studies have shown that once bacteria adhere...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L79/00C08L33/02C08K3/08C09D179/00C09D133/02C09D5/14C09D5/16C08J5/18C08F220/06C08F220/24C08J3/24A01N47/44A01N59/16A01P1/00
CPCC09D179/00C09D5/14C09D5/1662C08J5/18C08F220/06C08J3/24A01N47/44A01N59/16C08J2379/00C08J2433/16C08J2333/16C08K2003/0806C08L33/16C08F220/24
Inventor 李文婷李学于欢任玉芳李森刘朋
Owner UNIV OF JINAN
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