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Diacetyl acyclovir production solvent recovery method and solvent recovery device

A diacetyl acyclovir, solvent recovery device technology, applied in the field of solvent recovery, can solve the problems of inability to achieve clean production, failure of solvent recovery and mechanical application, etc., to achieve the effect of reducing production costs and reasonable treatment

Inactive Publication Date: 2020-03-24
HUBEI HONGYUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the reaction solution in the above method is simple to handle, and the solvent cannot be recovered and used mechanically, so clean production cannot be achieved.

Method used

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  • Diacetyl acyclovir production solvent recovery method and solvent recovery device
  • Diacetyl acyclovir production solvent recovery method and solvent recovery device
  • Diacetyl acyclovir production solvent recovery method and solvent recovery device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A kind of diacetyl acyclovir production solvent recovery method, comprises the following steps:

[0030] (1) Recover fraction A from the waste liquid obtained during the production of diacetyl acyclovir at a temperature of 128±2°C and a pressure of normal pressure; fraction A contains toluene, acetic anhydride, and acetic acid.

[0031] (2) After fraction A is recovered, the bottom material is obtained; the bottom material is subjected to vacuum distillation, and fraction B is collected at a temperature of 140±2°C and a pressure of -0.098MPa; in fraction B, 2-oxa- The mass fraction of 1,4-butanediol diethyl ester≥98.6%;

[0032] (3) When there is no obvious distillate, stop heating, turn on the circulating water to cool down to 75±2°C, discharge the remaining materials, and transfer the solid residue to the three-waste furnace for incineration.

[0033] The process flow chart of above-mentioned solvent recovery method is as figure 1 As shown, the solvent recovery devi...

Embodiment 2

[0036] A kind of diacetyl acyclovir production solvent recovery method, comprises the following steps:

[0037] (1) Recover fraction A from the waste liquid obtained during the production of diacetyl acyclovir at a temperature of 122±2°C and a pressure of normal pressure; fraction A contains toluene, acetic anhydride, and acetic acid.

[0038] (2) After fraction A is recovered, the bottom material is obtained; the bottom material is subjected to vacuum distillation, and fraction B is collected at a temperature of 132±2°C and a pressure of -0.098MPa; in fraction B, 2-oxa- The mass fraction of 1,4-butanediol diethyl ester≥98.1%;

[0039] (3) When there is no obvious distillate, stop heating, turn on the circulating water to cool down to 72±2°C, discharge the remaining materials, and transfer the solid residue to the three-waste furnace for incineration.

[0040] The solvent recovery device corresponding to the above solvent recovery method may be any suitable solvent recovery d...

Embodiment 3

[0043] A kind of diacetyl acyclovir production solvent recovery method, comprises the following steps:

[0044] (1) Recover fraction A from the waste liquid obtained during the production of diacetyl acyclovir at a temperature of 126±2°C and a pressure of normal pressure; fraction A contains toluene, acetic anhydride, and acetic acid.

[0045](2) After fraction A is recovered, the bottom material is obtained; the bottom material is subjected to vacuum distillation, and fraction B is collected at a temperature of 143±2°C and a pressure of -0.098MPa; in fraction B, 2-oxa- The mass fraction of 1,4-butanediol diethyl ester is ≥98.5%;

[0046] (3) When there is no obvious distillate, stop heating, turn on the circulating water to cool down to 78±2°C, discharge the remaining materials, and transfer the solid residue to the three-waste furnace for incineration.

[0047] The solvent recovery device corresponding to the above solvent recovery method may be any suitable solvent recover...

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Abstract

The invention discloses a diacetyl acyclovir production solvent recovery method and a solvent recovery device. The solvent recovery method includes the steps of: (1) recovering a fraction A from wasteliquid obtained during diacetyl acyclovir production under the conditions of a temperature of 120-130DEG C and a normal pressure; (2) acquiring a base material at the end of the fraction A recovery,carrying out reduced pressure distillation on the base material, and collecting a fraction B under the conditions of a temperature of 130-145DEG C and a pressure of -0.098MPa; wherein the mass fraction of 2-oxa-1, 4-butanediol diethyl ester in the fraction B is greater than or equal to 98%; and (3) when no obvious fraction is distilled out, stopping heating, starting circulating water cooling to 70-80DEG C, and discharging the residual material. By adopting the method for solvent recovery, the waste liquid treatment is reasonable, the solvent is fully separated and recycled, thus achieving clean production, also recovering the reaction raw materials, and lowering the production cost.

Description

technical field [0001] The invention relates to the technical field of solvent recovery, in particular to a solvent recovery method for diacetyl acyclovir production and a solvent recovery device. Background technique [0002] The chemical name of acyclovir is 9-[(2-hydroxyethoxy)methyl]-guanine, which is a highly efficient and broad-spectrum antiviral drug, which has been included in the national basic treatment drugs and has a large market demand. The drug is highly effective against type I and type II herpes simplex and varicella zoster viruses, and with the deepening of people's research, this type of drug can also be applied to anti-HIV virus. Since acyclovir was listed in the UK in 1981, its synthesis method and production process research have been paid attention to by people, and there are many synthesis methods so far. [0003] The Chinese Patent Application No. 201210194712.2 discloses a synthesis method of diacetyl acyclovir: guanine and acetic anhydride are firs...

Claims

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Application Information

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IPC IPC(8): C02F1/04C02F1/06
CPCC02F1/04C02F1/06
Inventor 杨明高邓支华方耀晏浩哲潘云渠喻莎莎童武宋伟李晓晖王训邓洋周拥军徐诚黄佐程思远周敏
Owner HUBEI HONGYUAN PHARMA
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