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Levodropropizine-guaifenesin capsule and preparation method thereof

A technology of levoropropazine and guaiacol glyceryl ether, which is applied in the field of levorfeetol capsules and preparation thereof, can solve the problems of many auxiliary materials, complicated operation steps, unstable mixing and the like, and achieves production cost saving and good quality Dissolution, the effect of simple preparation process

Active Publication Date: 2020-03-31
太阳升(亳州)生物医药科技有限公司
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

Using this method solves the problem of unstable mixing of levodropropizine and guaiacol glyceryl ether, but the method has complicated operation steps and many auxiliary materials used, which is not suitable for large-scale industrial production
[0006] Therefore, the prescription of levodropropizine guaiacol preparation still needs to be improved

Method used

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  • Levodropropizine-guaifenesin capsule and preparation method thereof
  • Levodropropizine-guaifenesin capsule and preparation method thereof
  • Levodropropizine-guaifenesin capsule and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0028] Embodiment 1: experimental research on the compatibility of raw materials and auxiliary materials

[0029] Referring to the requirements of the "Basic Technical Guidelines for the Research of Chemical Drug Preparations", separate raw materials, excipients, and mixed powders of raw materials and auxiliary materials were taken, and the influencing factors (light, high temperature, etc.) test.

[0030] Illumination test: Expose the raw materials, excipients, and mixed powders of raw and excipient materials in various ratios to the light of 4500±500Lx for 10 days, take samples, and detect the appearance properties and related substances.

[0031] High temperature test: the raw materials, excipients, and mixed powders of raw and excipient materials in different proportions are set out in two forms of weighing bottles (without lids) and lids respectively, and placed at a high temperature of 60°C for 10 days, sampling, and inspection of appearance properties and related subst...

Embodiment 2-21

[0044] Example 2-21 Prescription and preparation method of levoguaicol capsules

Embodiment 2

[0045] Table 1 Example 2-6 Levoguaiacol Capsules Prescription

[0046]

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Abstract

The invention relates to a levodropropizine-guaifenesin capsule and a preparation method thereof. The capsule comprises the following components, by total weight: 40 to 80 percent of levodropropizineand guaifenesin as active ingredients, 10 to 60 percent of a filling agent, 0 to 10 percent of a disintegrating agent, 0 to 10 percent of a bonding agent and 0.2 to 10 percent of a lubricating agent.The weight ratio of the active ingredients to the filling agent is 1: 1.5 to 4: 1. According to the invention, a problem that the two active ingredients are easy to discolor when meeting light and moisture during mixing is solved by lots of prescription screening and raw material-auxiliary material compatibility studies. The prepared levodropropizine-guaifenesin capsule has advantages of good disintegration, high dissolution rate and high stability and meets the drug quality standard.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to levoguaicol capsules and a preparation method thereof. Background technique [0002] Antitussive and expectorant therapy is a commonly used drug treatment regimen in clinical practice to relieve frequent, severe productive coughs, improve cough efficiency, and help clear the airways. While better treating respiratory infections, avoid serious complications caused by frequent and severe coughing, as well as adverse effects on work, life and patients' psychology. [0003] At present, the combination of expectorants and antitussives is common at home and abroad. For the purpose of improving patients' medication compliance, saving treatment costs and increasing the production capacity of the drug production process, many compound preparations have been launched on the market. However, the antitussives in the compound prescriptions currently on the market in China all use c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/495A61K9/48A61P11/10A61P11/14A61K31/085
CPCA61K31/495A61K31/085A61K9/485A61P11/14A61P11/10
Inventor 雷文枚孙关军张瑜杨希何莉
Owner 太阳升(亳州)生物医药科技有限公司
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