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Traditional Chinese medicine composition and application thereof for preventing and treating systemic sclerosis

A technology of composition and topical medicine, which is applied in the direction of drug combination, drug delivery, allergic diseases, etc., can solve the problems of poor curative effect and serious side effects of western medicine, and achieve the effect of improving fingertip ulcer symptoms, safety and no side effects

Active Publication Date: 2021-10-01
ZHEJIANG PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to address the problem of poor curative effect and large toxic and side effects of Western medicine for the treatment of SSc, to provide a Chinese medicine composition with good curative effect and high safety for treating scleroderma and its application, and its preparation using the composition hand cream

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Case 1: Lin, female, 56 years old, had systemic sclerosis for more than 3 years. Her hands turned white and purple when exposed to cold, accompanied by skin sclerosis on the fingertips. The effect is poor, and the symptoms worsen after winter, sometimes with tingling and numbness at the fingertips, and the nailfold microcirculation is poor. During the hospitalization in our hospital, I applied "Hard Skin No. 1 Hand Mask Cream" to my hands every night before going to bed, and wore disposable film gloves, fixed between the wrists with rubber bands, washed with warm water in the morning of the next day, and used continuously for 2 weeks , I felt that my hands turned white and purple when I was cold, and the tingling and numbness improved. After being discharged from the hospital, I continued to use it for 1 month, and the hardening of the fingertip skin also improved. The original inelastic hand skin can be pinched, and the microcirculation of the nail fold Blood flow has ...

Embodiment 2

[0021] Case 2: Zhang, female, 62 years old, had scleroderma for more than 5 years. Her hands turned white and purple without obvious incentives, accompanied by cold fingertips, and the skin felt hard and tense. Unable to heal for several months, he had been treated with glucocorticoids, bosentan (a vascular endothelin receptor antagonist that is expensive, at his own expense, and used off-label), alprostadil and other drugs for several months, but the symptoms were not relieved obviously. During the hospitalization in our hospital, I applied "Hard Skin No. 1 Hand Mask Cream" to my hands every night before going to bed, and wore disposable film gloves, fixed between the wrists with rubber bands, washed with warm water in the morning of the next day, and used continuously for 10 days , I felt that my hands were white and purple, and my fingers felt cold and tense. I continued to use it for 2 months after I was discharged from the hospital. White hair and purple condition.

[00...

Embodiment 3

[0025]Case 3: Mr. Fang, male, 64 years old, had scleroderma for more than 6 years, with hard skin all over the body, accompanied by repeated ulceration on the fingertips that was difficult to heal. After several years of treatment with vascular drugs, the symptoms were not relieved satisfactorily. During the hospitalization in our hospital, "Hard Skin No. 1 Hand Mask Cream" was applied to the hard skin, trunk and limbs (except hands) every night before going to bed, and wrapped Plastic wrap, wear disposable film gloves on hands, wash with warm water in the early morning of the next day, and use it continuously for 3 weeks. The feeling of skin stiffness and tightness has improved. After being discharged from the hospital, I have continued to use it for 3 months. There is relief.

[0026] The amount of raw materials used in this case is: 60 grams of Centella asiatica, 40 grams of Astragalus membranaceus, 60 grams of Caulis Spatholobus, 20 grams of raw rhubarb, 25 grams of angeli...

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Abstract

The invention relates to the application of a traditional Chinese medicine composition for preparing hand mask cream and the hand mask cream prepared by using the composition. The traditional Chinese medicine composition mainly includes the following traditional Chinese medicine raw materials in mass proportions: 40-60 parts of Centella asiatica, 30-40 parts of Astragalus membranaceus, 40-60 parts of Caulis Spatholobus, 10-20 parts of raw rhubarb, 15 parts of angelica 25 parts, 20~30 parts of Chuanxiong, 20~30 parts of Salvia, 15~25 parts of Guizhi, 5~10 parts of comfrey, and 10~15 parts of Scutellaria baicalensis. The traditional Chinese medicine composition of the invention has a good improvement effect on atrophy and ulcer symptoms caused by systemic sclerosis, is safe and has no toxic and side effects, and provides a new way for the prevention and treatment of systemic sclerosis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating scleroderma and its application, and a hand cream prepared by using the composition. Background technique [0002] Systemic sclerosis (SSc), also known as scleroderma, is a connective tissue disease characterized by skin inflammation, degeneration, thickening, and fibrosis, followed by hardening and atrophy. In systemic sclerosis, in addition to degeneration of the skin, synovium, and finger (toe) arteries, internal organs such as the digestive tract, lungs, heart, and kidneys may also be affected. The age of onset of SSc is mostly between 30 and 50 years old, and the male to female ratio is 1:7~12. The etiology is still unclear, but it may be caused by genetic, environmental factors, immune abnormalities and other factors, resulting in damage to endothelial cells and fibroblasts, resulting in fibrosis and ischemia. [0003] Modern medicine has no specific drugs in the t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/708A61K36/756A61K9/06A61P37/02A61P17/02A61K36/9068
CPCA61K9/0014A61K9/06A61K36/17A61K36/23A61K36/232A61K36/236A61K36/30A61K36/31A61K36/36A61K36/481A61K36/486A61K36/537A61K36/539A61K36/54A61K36/65A61K36/708A61K36/71A61K36/756A61K36/9068A61K47/06A61P17/00A61P17/02A61P37/02A61K2300/00
Inventor 徐丽萍宋欣伟王吉安
Owner ZHEJIANG PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE