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Traditional Chinese medicine spray for treating ornithobacterium rhinotracheale of green-shell egg laying hens and preparation method thereof

A technology for green-shelled laying hens and sprays, which is applied in the directions of aerosol delivery, antibacterial drugs, pharmaceutical formulations, etc., can solve problems such as inability to use antibiotics for prevention or treatment, achieve no toxic side effects, obvious effects, and ensure drug concentration. Effect

Active Publication Date: 2020-04-10
SICHUAN AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, vaccines are mainly used to prevent the disease, but there is no relevant vaccine in my country; at the same time, the bacteria have developed resistance to multiple antibiotics, and antibiotics cannot be used for prevention or treatment on green-shell laying hens. Therefore, It is imminent to develop a new type of anti-nasopharyngeal ornithosis with high efficiency, low toxicity and no drug residue

Method used

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preparation example Construction

[0025] The present invention also includes a preparation method of a traditional Chinese medicine spray for treating nasotracheal ornithosis of green-shell laying hens, comprising the following steps:

[0026] Step 1, weighing: by weight, weigh the following components: 15-20 parts of Cortex Mori, 15-20 parts of perilla leaves, 10-15 parts of Cimicifuga, 5-12 parts of Rubia;

[0027] Step 2. Mix the weighed components, add water for injection 8 times the mass of the medicinal materials, carry out the first distillation and extraction at a temperature of 90°C-100°C for 1.5 hours-2.5 hours, and collect the distillate, which is The first aromatic water, wherein the volume-to-mass ratio (ml / g) of the first aromatic water to Cortex Mori is 100:375-100:500, and then the medicinal residue is distilled for the second time at 90°C-100°C Extract for 1 hour to 1.5 hours, collect the distillate, which is the second aromatic water, wherein the volume of the second aromatic water and the fi...

Embodiment 1

[0042] Step 1, get mulberry white bark 45kg, perilla leaf 40kg, cohosh 35kg, madder 30kg, add the water for injection of 8 times of Chinese medicine quality, carry out first distillation extraction 2 hours under 100 ℃ of temperature conditions, collect distillate 100L, That is, the first aromatic water, under the temperature condition of 100 ℃, the medicinal residue is distilled and extracted for the second time for 1.5 hours, and 50 L of distillate is collected, which is the second aromatic water. , add 300ml of co-solvent Tween 80 and mix well to obtain the prepared third aromatic water;

[0043] Step 2, prepare the third aromatic water prepared by the same method as above, for subsequent use;

[0044] Step 3. After collecting the third aromatic water, add 8 times the amount of water for injection to the medicinal residues, decoct twice for 45 minutes each time, filter through three layers of gauze, and combine the two decoctions with the prepared solution obtained in step 1...

Embodiment 2

[0051] Step 1, get 37.5kg of mulberry white bark, 50kg of perilla leaves, 25kg of cohosh, and 30kg of madder, add 8 times of water for injection of Chinese medicine quality, carry out first distillation and extraction under 90 ℃ of temperature conditions for 2.5 hours, collect 100L of distillate , is the first aromatic water, under the temperature condition of 90 ℃, the medicinal residue is distilled and extracted for the second time for 2.5 hours, and 50L of distillate is collected, which is the second aromatic water, and the two aromatic waters are combined with 150L and distilled for the third time to 35L, add 200ml of co-solvent Tween 80, and mix well to obtain the prepared third aromatic water;

[0052] Step 2, prepare the third aromatic water prepared by the same method as above, for subsequent use;

[0053] Step 3. After collecting the third aromatic water, add 8 times the amount of water for injection to the medicinal residues, decocted twice for 60 minutes each time, ...

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Abstract

The invention discloses a traditional Chinese medicine spray for treating ornithobacterium rhinotracheale of green-shell egg laying hens and a preparation method thereof. The traditional Chinese medicine spray is prepared from the following components in parts by weight: 15 to 20 parts of cortex mori radicis, 15 to 20 parts of folium perillae, 10 to 15 parts of rhizoma cimicifugae and 5 to 12 parts of radix rubiae. The preparation method comprises the following steps: mixing the above components, adding water for injection, carrying out distillation extraction three times to obtain third aromatic water, and adding a cosolvent, namely Tween 80 into the third aromatic water to obtain blended third aromatic water; adding water for injection accounting or 8 times of herbal residues, carrying out decocting and filtering, combining a decoction and the prepared third aromatic water, adding ethanol, conducting concentrating to obtain a concentrated solution, and adjusting the pH value of the concentrated solution; and adding the prepared third aromatic water, benzoic acid and nipagin into the concentrated solution after pH adjustment, adding water for injection until a fixed volume is obtained, and performing sterilizing to obtain the spray. The spray disclosed by the invention has an obvious effect on treating ornithobacterium rhinotracheale of the green-shell egg laying hens.

Description

technical field [0001] The invention belongs to the field of veterinary medicine products for poultry, and in particular relates to a traditional Chinese medicine spray for treating nasotracheal avian bacillus disease of green-shell laying hens and a preparation method thereof. Background technique [0002] The large-scale development of the chicken industry has led to the large-scale and intensive development of broiler and laying hens in the breeding process. The three-dimensional layer cages are used to raise them, showing a high-density feeding method. Green-shell hens, named after producing green-shell eggs, are characterized by the green shell color of the eggs. It is a unique poultry species in China and is listed as a "National Special Resource Protection Project" by the Ministry of Agriculture. This chicken breed has strong disease resistance, wide adaptability, likes to eat green grass and vegetable leaves, and its feeding management is similar to other chickens....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61K9/12A61P31/04A61P29/00A61P11/06
CPCA61K9/0078A61K9/12A61K36/535A61K36/605A61K36/71A61K36/74A61K47/26A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P11/06A61P29/00A61P31/04A61K2300/00
Inventor 舒刚黄远玲任静唐子婷袁宇彭佳昊张远南徐丹欧达亮苏毅赵小玲
Owner SICHUAN AGRI UNIV
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