Metabonomics-based compound lightyellow sophora root injection anti-liver-cancer mechanism research method

Abstract

The invention, which belongs to the technical field of metabonomics, particularly relates to a metabonomics-based compound lightyellow sophora root injection anti-liver-cancer mechanism research method. According to the invention, a nuclear magnetic resonance technology is adopted to detect urine metabolites of rats suffering from the liver cancer caused by diethylnitrosamine and urine metabolitesof rats intervened by a compound lightyellow sophora root injection; a biomarker for the liver cancer caused by diethylnitrosamine is found through a multivariate statistical analysis method, and the biomarker is called back by the compound lightyellow sophora root injection, so that recognition and high-throughput analysis of a liver cancer treatment mechanism of the compound lightyellow sophora root injection are realized. The invention aims at solving the problems that the existing pharmacological evaluation method is single and the action mechanism of the traditional Chinese medicine cannot be systematically and comprehensively evaluated. By pathway analysis on the biomarker, the action mechanism of the compound lightyellow sophora root injection for treating the liver cancer can beevaluated comprehensively, efficiently and quickly from the overall level without deviation, and demonstrative research is provided for clarification of traditional Chinese medicine metabonomics and the action mechanism.

Description

technical field [0001] The invention belongs to the technical field of metabolomics, and in particular relates to a research method for the anti-hepatic cancer mechanism of compound Kushen injection based on metabolomics. Background technique [0002] Metabolomics is a multi-parameter quantitative analysis of the dynamic metabolic response of biological systems to pathological, physiological stimuli, or genetic changes. It can comprehensively understand the pathological change process and the metabolism of substances in the body by revealing the changing rules of metabolites in the metabolic process. Pathways have been widely used in biology and medical related fields, such as disease diagnosis, drug mechanism of action and toxicology research. Metabolomics studies the overall and systematic changes of endogenous metabolites caused by drugs, which can directly reflect the overall profile of biochemical processes and states in the body, which coincides with the holistic and s...

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Problems solved by technology

[0004] Aiming at the problem that the existing pharmacological methods cannot completely and comprehensively explain the mechanism of the traditional Chinese medicine Compound Kushen Injection in the treatment of liver cancer, the present invention provides a metabolomics-based research method for the anti-liver cancer mechanism of Compound Kushen Injection

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