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Application of a kind of deoxydicholide or isodeoxydicholide in the preparation of anti-pulmonary fibrosis medicine

A technology for pulmonary fibrosis and dandelion, applied in the field of medicine, can solve the problems such as no reports and applications of anti-fibrosis treatment yet.

Active Publication Date: 2022-06-07
仁合熙德隆药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Deoxydicholide and isodeoxydicholide are two kinds of natural products, both of which are isomers. There have been many research reports on their activities, but they have not been seen in anti-fibrosis. Reports and Applications in Therapeutics

Method used

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  • Application of a kind of deoxydicholide or isodeoxydicholide in the preparation of anti-pulmonary fibrosis medicine
  • Application of a kind of deoxydicholide or isodeoxydicholide in the preparation of anti-pulmonary fibrosis medicine

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 1. Test materials

[0017] The purity of deoxydigilide (CAS: 29307-03-7) was 97.5%, and the purity of isodeoxydigilide (CAS: 38927-54-7) was 98.0%, purchased from Shanghai Ulva Test Biotechnology Co., Ltd. .

[0018] Human embryonic lung fibroblasts HFL1 were purchased from ATCC and used after resuscitation according to conventional methods.

[0019] Fetal bovine serum and F12K medium were purchased from Gbico Company in the United States.

[0020] Penicillin, streptomycin, and pancreatin were purchased from Biyuntian Biology.

[0021] The brand of 96-well plate and 6-well plate is Corning.

[0022] 2. Test method

[0023] 1. Culture of human embryonic lung fibroblasts

[0024] Human embryonic lung fibroblasts HFL1 were cultured in F12K medium containing 10% fetal bovine serum, 100 U / mL penicillin and 100 μg / mL streptomycin at 37°C in 5% CO. 2 Cultured in a conventional incubator and passaged with 0.25% trypsin. Human embryonic lung fibroblasts HFL1 in logarithmi...

Embodiment 2

[0040] The composition of the formula: an anti-pulmonary fibrosis tablet, the formula includes 10 mg of deoxydebililide or isodeoxydebichololide, 90 g of starch, and 3 g of magnesium stearate.

[0041] Preparation process: take deoxydibilinolide or isodeoxydibilolide, add starch and magnesium stearate and mix them evenly to prepare granules, dry and press into tablets.

Embodiment 3

[0043] Formulation composition: an anti-pulmonary fibrosis capsule, the formula includes 10 mg of deoxydebichololide or isodeoxy debichololide, 90 g of starch, and 3 g of magnesium stearate.

[0044] Preparation process: take deoxydibilinolide or isodeoxydibilolide, add starch and magnesium stearate and mix them evenly to prepare granules, dry and pack into capsules.

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Abstract

The invention discloses the application of deoxydicholide or isodeoxydicholide in the preparation of anti-pulmonary fibrosis medicine. The research of the present invention found that deoxydicholide or isodeoxydicholide can effectively inhibit the proliferation of human embryonic lung fibroblast HFL1, and the results of Western Blot showed that deoxydicholide or isodeoxydicholide The inhibitory effect of choleralide on the proliferation of human embryonic lung fibroblasts HFL1 may be related to the arrest of human embryonic lung fibroblasts in the G1 phase by down-regulating the expression of cyclins Cyclin D1 and CDK4. Therefore, deoxycholate or isodeoxycholine has the prospect of being developed as an anti-pulmonary fibrosis drug.

Description

technical field [0001] The invention belongs to the field of medicine, relates to the discovery of anti-pulmonary fibrosis drugs, and in particular relates to the application of a deoxydebibilide or isodeoxydebibilide in the preparation of anti-pulmonary fibrosis drugs. Background technique [0002] Pulmonary fibrosis (pulmonary fibrosis) is an immune-mediated chronic inflammatory disease characterized by alveolar interstitial inflammatory cell infiltration, abnormal proliferation of fibroblasts and collagen deposition. It is a common outcome of many interstitial lung diseases with different etiologies. , the clinical manifestations are mainly progressive dyspnea, and patients eventually die of respiratory failure. There is still no effective treatment. Therefore, it has become an urgent need for current medicine to find effective drugs against pulmonary fibrosis. [0003] Lung fibroblasts are differentiated from embryonic mesenchymal cells and constitute the main cellular c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61P11/00
CPCA61K31/365A61P11/00
Inventor 朱阳晨赵玲
Owner 仁合熙德隆药业有限公司
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