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Structured illumination microscopy with line scanning

A line-scanning, axis-based technology, used in microscopes, laboratory containers, nanotechnology, etc.

Pending Publication Date: 2020-05-01
ILLUMINA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Overlaying the sample 100 with an optical diffraction grating pattern 102 having a known lower spatial frequency results in moiré fringes, although the sample 100 may include higher spatial frequencies that are not resolved

Method used

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  • Structured illumination microscopy with line scanning
  • Structured illumination microscopy with line scanning
  • Structured illumination microscopy with line scanning

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Embodiment Construction

[0037]As used herein, with respect to diffracted light emitted by a diffraction grating, the term "order" or "order" is intended to mean the number of integer wavelengths representing the number of light coming from adjacent slits of the diffraction grating that constructively interfere. The path length is poor. The term "zeroth order" or "zeroth order maximum" is intended to refer to the central bright fringe emitted by a diffraction grating in which there is no diffraction. The term "first order" is intended to refer to two bright fringes emitted on either side of the zero order fringe, where the path length difference is ±1 wavelength.

[0038] As used herein, with respect to a sample, the term "spot" or "feature" is intended to mean a point or region in a pattern that can be distinguished from other points or regions by relative position. Individual spots may include one or more molecules of a particular type. For example, a spot may comprise a single target nucleic acid...

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Abstract

Techniques are described for reducing the number of angles needed in structured illumination imaging of biological samples through the use of patterned flowcells, where nanowells of the patterned flowcells are arranged in, e.g., a square array, or an asymmetrical array. Accordingly, the number of images needed to resolve details of the biological samples is reduced. Techniques are also described for combining structured illumination imaging with line scanning using the patterned flowcells.

Description

[0001] Cross References to Related Applications [0002] This application claims U.S. Provisional Patent Application No. 62 / 621,570, filed January 24, 2018, entitled "Structured Illumination Microscopy With Line Scanning," and filed March 20, 2018, entitled "Structured Illumination Microscopy With Line Scanning" Priority of Dutch Patent Application No. N2020623. The entire content of each of the foregoing applications is incorporated herein by reference. Background technique [0003] Many recent advances in biological research have benefited from improved methods for analyzing and sequencing nucleic acids. For example, the Human Genome Project has determined the entire sequence of the human genome, which it is hoped will lead to further discoveries in areas ranging from disease treatment to basic science development. Recently, a number of new DNA sequencing techniques have been reported, based on the massively parallel analysis of unamplified or amplified single molecules, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N11/00G01N21/76G01N33/48B82Y20/00
CPCB01L3/5027B01L2300/0819B01L2300/0887G01N21/6452G01N21/6458G01N2021/6419G01N2021/6482G01N2201/0635G02B21/16G02B21/367G02B27/425G02B27/60G02B21/0032G02B21/0072G01N11/00G01N21/76G02B21/0076
Inventor 郭明浩
Owner ILLUMINA INC
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