Unlock instant, AI-driven research and patent intelligence for your innovation.
A fluorescent covalent organic framework material and its preparation method and application
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of covalent organic framework and framework materials, applied in the field of chemistry and biology, materials, to achieve good dispersion and stability, simple synthesis steps and high yield
Active Publication Date: 2022-03-29
临沂鑫皓中药饮片有限公司
View PDF0 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0004] However, due to limited organic reaction types and monomer types, the simple and efficient synthesis of COFs faces many challenges, and through previous literature research, we found that there is no public report on the synthesis of fluorescent COFs by simple methods under normal pressure.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0043] Intermediate Synthesis: N, N, N ', N'-tetraphenyl - [1,1-biphenyl] -4,4-diamine (TPB 5.0 g, 10.2 mmol) and imidazole (5.1 g, 61.5) Mmol) Added to 250 ml of two round bottom flasks, then 90 ml of acetonitrile. In a nitrogen atmosphere (N 2 The trifluoroacetic anhydride (17.3 mL, 0.123 mol) was added dropwise. Reflow mixture until TPB is completely consumed (monitoring by thin layer chromatography). The reaction solution was poured into 1L water to dissolve the yellow powder precipitate. The filter cake was washed with water until the filtrate became colorless to obtain a product TPB-IOS: yellow solid (15.4 g, 98.3%).
[0044]Synthesis: The aggolithine product (TPB-IOS, 10G, 6.5 mmol) was dissolved in 200 ml of THF. Then pumped the HCl solution (100 mL, by adding 21.0 ml of concentrated HCl to 79.0 mL H) 2 O-prepared 2.5 mol·L -1 . The reaction solution was refluxed for 12 hours. The reaction solution was cooled to room temperature and formed an orange solid. The reaction mix...
Embodiment 2
[0054] Other synthetic conditions are in Example 1. Change the conditions during the COF synthesis:
[0055] TPB and TMB were mixed in the chloroform solution in molar ratio 2: 4, and catalyst formic acid with a TPB molar ratio of 0.5 was added, and three days were refluxed at 65 ° C. Filtration was washed with chloroform to give a pure brown powder COF product with a yield of 93%.
Embodiment 3
[0057] Other synthetic conditions are in Example 1. Change the conditions during the COF synthesis:
[0058] TPB and TMB were mixed in a ratio of molar ratio of 2: 4 in a toluene solution, and a catalyst acetic acid having a TPB molar ratio of 0.2 was added, and 40 hours were refluxed at 115 ° C. The filtration was filtered and washed with toluene to give the pure brown powder COF product with a yield of 91%.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Property
Measurement
Unit
size
aaaaa
aaaaa
size
aaaaa
aaaaa
Login to View More
Abstract
The invention relates to a preparation method and application of a covalent organic framework material, which is characterized in that a porous covalent organic framework material is synthesized by a low-temperature reflux method by synthesizing and using highly conjugated monomers. The synthesized material has good dispersibility in solvent and exhibits special fluorescence properties. The covalent organic framework material has a large specific surface area, can realize the loading of various enzymes and drugs, and has remarkable responsive release performance. In particular, the material has low cytotoxicity, and the slow-release mode and route of the drug can significantly improve the utilization of the enzyme and the drug after being ingested by the cells, and improve the therapeutic effect of the drug.
Description
Technical field [0001] The present invention belongs to the field of materials, chemistry, and biotechnology, and specific relates to a covalent organic frame material and a preparation method thereof. Background technique [0002] A covalent organic frame (COF) is a class of porous organic polymer crystals connected by light elements such as carbon, hydrogen, oxygen, nitrogen, boron, or the like. Due to its special structural and nature, it exhibits huge application potential in the fields of gas adsorption, catalysis, energy storage, drug delivery and photovoltaic equipment. In recent years, COF's synthesis, nature and application research have been concerned with more and more research workers (see T. MA, E. A. Kapustin, S. X. Yin, Liang, Z. Zhou, J. Niu, L.-H. LI, Y. WANG, J. SU and J. LI, Science, 2018, 361, 48-52; H.wang, Z. Zeng, P. Xu, LI, G. Zeng, R. XIAO, Z. TANG, D. Huang, L. Tang andc. LAI, Chem. SOC. Rev., 2019, 48, 488-516.) The synthesis of new COF materials has an...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More