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Liquid feed and method for constructing cynomolgus monkey alcoholic liver disease model

An alcoholic liver disease and liquid feed technology is applied in the field of liquid feed for the construction of cynomolgus monkey alcoholic liver disease model, which can solve the problems of large differences in metabolism and large differences in the process of disease, so as to ensure nutritional needs, improve the success rate of modeling, The effect of solving the problem of animal blood alcohol concentration

Pending Publication Date: 2020-05-12
湖北天勤生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the structure and metabolism of mice and human body are quite different, and the pathological process of human alcoholic liver disease is quite different.

Method used

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  • Liquid feed and method for constructing cynomolgus monkey alcoholic liver disease model
  • Liquid feed and method for constructing cynomolgus monkey alcoholic liver disease model
  • Liquid feed and method for constructing cynomolgus monkey alcoholic liver disease model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] This example provides a liquid feed for building a model of alcoholic liver disease in cynomolgus monkeys, including liquid feed A and liquid feed B.

[0034] Among them, each liter of liquid feed A contains corn 100±20g, soybean meal 30±10g, flour 35±10g, wheat bran 45±20g, fish meal 30±20g, brewer’s yeast 10±5g, vegetable oil 50±20g, calcium hydrogen phosphate 2.5± 1.5g, stone powder 4.5±1.5g, salt 4±4g, ethanol 75±20g and the rest water.

[0035] Among them, each liter of liquid feed B contains corn 250±25g, soybean meal 90±35g, flour 50±20g, wheat bran 100±30g, fish meal 40±20g, brewer’s yeast 10±5g, vegetable oil 70±20g, calcium hydrogen phosphate 6± 4g, stone powder 6g, salt 4±4g and the rest of water.

Embodiment 2

[0037] This embodiment provides a liquid feed for constructing a cynomolgus monkey model of alcoholic liver disease. g.

Embodiment 3

[0039] This embodiment provides a method for constructing a cynomolgus monkey alcoholic liver disease model, comprising the following steps:

[0040] (1) Get 12 female cynomolgus monkeys with a body weight of 3-5kg, and prepare the liquid feed for constructing the alcoholic liver disease model of cynomolgus monkeys in Example 2 and the solid feed for routinely feeding cynomolgus monkeys (monkey maintenance feed, Beijing Keao Xieli Feed Co., Ltd.).

[0041] (2) In the first week, the cynomolgus monkeys used for modeling were adaptively fed by mixing conventional solid feed and liquid feed B in Example 2 and gradually increasing the proportion of liquid feed B and decreasing the proportion of conventional solid feed.

[0042] In this step, the way to gradually increase the proportion of liquid feed B and reduce the proportion of conventional solid feed is to mix liquid feed B and conventional solid feed according to the ratio of 0%:100%, 20%:80%, 40%:60%, The ratio of 60%:40%, ...

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Abstract

The invention relates to a liquid feed and method for constructing a cynomolgus monkey alcoholic liver disease model. The liquid feed comprises a liquid feed A and a liquid feed B which respectively contain specific components. According to the cynomolgus monkey alcoholic liver disease model construction method, cynomolgus monkey alcoholic liver disease modeling is performed through a progressivetransition manner of sequentially adopting the combination of conventional solid feed and the liquid feed B, the combination of the liquid feed B and the liquid feed A, and the liquid feed A. The liquid feed more fit the human alcoholic liver disease occurrence environment, anorexia, dehydration, poor state and other situations of modeling animals can be effectively avoided, and thereby the modeling success rate is improved.

Description

technical field [0001] The invention relates to the technical field of medical animal models, in particular to a liquid feed and a method for constructing a cynomolgus monkey alcoholic liver disease model. Background technique [0002] More than 20% of the population in China suffers from liver diseases, including 90 million hepatitis B patients, 10 million hepatitis C patients, 173-310 million non-alcoholic fatty liver patients, 62 million alcoholic liver disease patients, 7 million liver cirrhosis patients, and 46 new cancers every year Thousands of cases. The morbidity and mortality of liver disease are high in China. [0003] "Guidelines for the Prevention and Treatment of Alcoholic Liver Diseases in China in 2018" pointed out that: Alcoholic hepatitis can occur if alcohol consumption exceeds 5 years, and the equivalent ethanol amount is ≥ 40 grams per day for men and ≥ 20 grams per day for women; hardening. Alcoholic hepatitis may also occur if there is heavy drinkin...

Claims

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Application Information

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IPC IPC(8): A23K50/00A23K10/30A23K10/37A23K10/22A23K10/18A23K20/158A23K20/26A23K20/20A23K20/22A23K20/105A23K20/168A01K67/02A61K49/00
CPCA23K50/00A23K10/30A23K10/37A23K10/22A23K10/18A23K20/158A23K20/26A23K20/20A23K20/22A23K20/105A23K20/168A01K67/02A61K49/0008Y02P60/87
Inventor 李一鸣
Owner 湖北天勤生物科技有限公司
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