Supercharge Your Innovation With Domain-Expert AI Agents!

Povidone-iodine effervescent tablet and preparation process thereof

An effervescent tablet, povidone-iodine technology is applied in the directions of artificially synthesized active ingredients of polymeric materials, drug delivery, active ingredients of iodine compounds, etc., and achieves the effects of stable content, simple preparation process and simple process.

Inactive Publication Date: 2020-05-15
山东正牧生物药业有限公司
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Effervescent tablet formulations with povidone-iodine as the main drug ingredient have also been reported, but most of them are limited to vaginal effervescent tablet formulations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Povidone-iodine effervescent tablet and preparation process thereof
  • Povidone-iodine effervescent tablet and preparation process thereof
  • Povidone-iodine effervescent tablet and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: A kind of povidone-iodine effervescent tablet and its preparation process

[0037]

[0038] Specifically, the preparation process is

[0039] 1) citric acid and sodium citrate to adjust the pH value of citric acid-sodium citrate buffer solution to 3.0-6.0, dissolving sodium deoxycholate and povidone-iodine in a mass ratio of 1:1 in Buffer solution, stirred and mixed, 40-55 ℃ rotary evaporated to dryness, passed through 200 mesh sieve, the mixture is set aside;

[0040] 2) Mix anhydrous citric acid and sodium bicarbonate in equal amounts and sieve evenly;

[0041] 3) After mixing the mixture of step 1) and step 2) uniformly according to the method of equal increase, spray 50% ethanol solution of polyethylene glycol 4000, and press into tablets.

Embodiment 2

[0042] Embodiment 2: A kind of povidone-iodine effervescent tablet and its preparation process

[0043]

[0044] The preparation process is as described in Example 1.

Embodiment 3

[0045] Embodiment 3: A kind of povidone-iodine effervescent tablet and its preparation process

[0046]

[0047] The preparation process is as described in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the technical field of preparations, in particular to a povidone-iodine effervescent tablet and a preparation process thereof. The effervescent tablet contains povidone iodine, an acidic reagent, an alkaline reagent, polyethylene glycol 4000 and other excipients. The preparation process comprises the steps: dissolving povidone iodine in a buffer firstly so as to maintain stability, then then performing rotary evaporation, performing sieving, and then performing thorough mixing with the alkaline reagent and acidic reagent so as to obtain the final product. It is found through acceleration tests that the content of povidone iodine is stable, and the disintegration time of the effervescent tablet has no basic change; and the preparation process is simple, and is suitable for industrial expanded production.

Description

technical field [0001] The invention relates to the technical field of preparations, in particular to a povidone-iodine effervescent tablet and a preparation process thereof. Background technique [0002] Povidone-iodine is a prodrug preparation, an amorphous compound formed by combining polyvinylpyrrolidone and iodine, containing 9% to 12% of available iodine, and is a new type of water-soluble iodine for external use. Compared with tincture of iodine (iodine solution), it has the characteristics of stable properties, good water solubility, non-irritating and volatile, mild and long-lasting effect, safe use, easy elution of chromatography, etc. It is an efficient, broad-spectrum, low-toxic disinfection fungicide. Its antibacterial mechanism is due to the surface activity and emulsification of povidone-iodine. On the one hand, the penetration of povidone-iodine is enhanced; A large amount enters the cell, and the leakage of the cell content leads to the death of the microo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/46A61K31/79A61K33/18A61P31/04
CPCA61K9/0007A61K9/0014A61K9/2018A61K9/2095A61K31/79A61K33/18A61P31/04
Inventor 王峰陈仕强高贵磊高永途臧正理
Owner 山东正牧生物药业有限公司
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com