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Laser coaxial ion excitation device

A laser and coaxial technology, applied in the direction of ion source/gun, dynamic spectrometer, particle separation tube, etc., can solve the problems of wide distribution, high preparation cost, unfavorable ion flight, etc., and achieve improved mass spectrometry resolution, reasonable structure setting, The effect of small spatial differences in ions

Pending Publication Date: 2020-05-15
ZHEJIANG DIGENA DIAGNOSTIC TECH CO LTD
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0002] The existing matrix-assisted laser desorption ionization time-of-flight mass spectrometry equipment has a complex structure, and it is difficult to adjust the laser excitation. The ion excitation is generally biased excitation, and the spatial distribution of the excited ion cloud is asymmetric and widely distributed, which is not conducive to ion flight after ion excitation. , the ionization efficiency is not ideal, the resolution is not ideal, and the preparation cost is high
The non-uniform distribution of space, non-uniform distribution of ion charge and non-uniform distribution of ion generation time generated by the existing bias excitation optical path are the key factors affecting the detection results of mass spectrometry

Method used

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  • Laser coaxial ion excitation device
  • Laser coaxial ion excitation device
  • Laser coaxial ion excitation device

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Embodiment Construction

[0018] The present invention will be further described below in conjunction with accompanying drawing and specific embodiment:

[0019] Such as Figure 1-3 As shown, a laser coaxial ion excitation device includes the center of the optical path and the ion transmission channel, the center of the optical path is empty, the center of the optical path is coaxial with the ion transmission channel, the ion transmission channel is perpendicular to the matrix carrier, and the laser focusing spot is non-uniform focusing , the optical path includes but not limited to the laser transmission optical path, visual monitoring optical path, visual lighting optical path, and light intensity monitoring optical path; wherein, the laser transmission optical path includes but not limited to the objective lens 10, the total mirror 9, the return mirror 8, the beam expander 4, the laser 3; the visual monitoring optical path includes but is not limited to the laser transmission mirror 5, the light sou...

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Abstract

The invention discloses a laser coaxial ion excitation device. The device comprises a light path center and an ion transmission channel, the light path center is hollow, the light path center is coaxial with the ion transmission channel, the ion transmission channel is perpendicular to a matrix carrier, laser focusing light spots are focused in a non-uniform way, and a light path comprises but isnot limited to a laser transmission light path, a visual monitoring light path, a visual illumination light path and a light intensity monitoring light path. The laser coaxial ion excitation device isreasonable in structural arrangement, wide in ion mass range, high in resolution and capable of effectively improving ion excitation abundance.

Description

Technical field: [0001] The invention relates to the field of matrix-assisted laser analysis ionization time-of-flight mass spectrometry analysis, in particular to a laser coaxial ion excitation device. Background technique: [0002] Existing matrix-assisted laser desorption ionization time-of-flight mass spectrometry equipment has a complex structure, and it is difficult to adjust the laser excitation. The ion excitation is generally biased excitation, and the spatial distribution of the excited ion cloud is asymmetric and widely distributed, which is not conducive to ion flight after ion excitation. , the ionization efficiency is not ideal, the resolution is not ideal, and the preparation cost is high. The non-uniform distribution of space, non-uniform distribution of ion charge and non-uniform distribution of ion generation time generated by the existing bias excitation optical path are the key factors affecting the detection results of mass spectrometry. Invention cont...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/16H01J49/40
CPCH01J49/164H01J49/40H01J49/025
Inventor 相双红
Owner ZHEJIANG DIGENA DIAGNOSTIC TECH CO LTD