Nanoparticles with multiple functions of photoacoustic imaging, photothermal therapy and drug loading

A photothermal therapy and nanoparticle technology, which is applied in the fields of materials and medicine, can solve problems that have never occurred before, and achieve the effects of narrow particle size distribution, uniform and controllable particle size, and simple preparation method.

Active Publication Date: 2021-09-24
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, combining ZIF-8, polypyrrole, and polysaccharides into a hybrid nanoparticle with photoacoustic imaging and photothermal therapy capabilities has broad application prospects, which have not appeared in previous reports.

Method used

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  • Nanoparticles with multiple functions of photoacoustic imaging, photothermal therapy and drug loading
  • Nanoparticles with multiple functions of photoacoustic imaging, photothermal therapy and drug loading
  • Nanoparticles with multiple functions of photoacoustic imaging, photothermal therapy and drug loading

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A hybrid nanoparticle for photoacoustic imaging and photothermal effect, comprising the following raw materials:

[0037] Zinc nitrate hexahydrate, 2-methylimidazole (2-MIM), pyrrole (Py), polysaccharide, initiator;

[0038] Zinc nitrate hexahydrate and 2-methylimidazole adopt respective methanol solutions;

[0039] Described initiator is anhydrous iron trichloride (FeCl 3 );

[0040] Described polysaccharide is the aqueous solution (molecular weight is 80000) of hydroxypropyl cellulose (HPC);

[0041] The preparation method of the hybrid nanoparticle comprises the following steps:

[0042] S1. Take 10.0ml of methanol solution of zinc nitrate hexahydrate (14.7mg / ml) in a round bottom flask, add 171.1μl of pyrrole, and stir magnetically (1000rpm) at 25°C for 10min.

[0043] S2. Add 10.0 ml of a methanol solution of 2-methylimidazole (8.1 mg / ml) to the solution in step S1, and continue stirring for 30 min.

[0044] S3. Add 20.0ml of an aqueous solution of hydroxyprop...

Embodiment 2

[0054] A hybrid nanoparticle for photoacoustic imaging and photothermal effect, comprising the following raw materials:

[0055] Zinc nitrate hexahydrate, 2-methylimidazole, pyrrole, polysaccharide, initiator;

[0056] Zinc nitrate hexahydrate and 2-methylimidazole adopt respective methanol solutions;

[0057] Described initiator is ammonium persulfate;

[0058] The polysaccharide is an aqueous solution of hydroxypropyl cellulose (molecular weight is 80000).

[0059] The preparation method of the hybrid nanoparticle comprises the following steps:

[0060] Step a. Take 10.0ml of methanol solution of zinc nitrate hexahydrate (14.7mg / ml) in a round bottom flask, add 171.1μl of pyrrole, and stir magnetically (1000rpm) at 25°C for 10min.

[0061] Step b. Add 10.0 ml of 2-methylimidazole in methanol (8.1 mg / ml) to the solution in step a, and continue stirring for 30 min.

[0062] Step c, add 20.0ml of an aqueous solution of hydroxypropylcellulose (50.0mg / ml) to the solution in s...

Embodiment 3

[0065] A hybrid nanoparticle for photoacoustic imaging and photothermal effect, comprising the following raw materials:

[0066] Zinc nitrate hexahydrate, 2-methylimidazole, pyrrole, polysaccharide, initiator;

[0067] Zinc nitrate hexahydrate and 2-methylimidazole adopt respective methanol solutions;

[0068] Described initiator is ferric trichloride anhydrous;

[0069] The polysaccharide is an aqueous solution of dextran (molecular weight is 100000);

[0070] The preparation method of the hybrid nanoparticle comprises the following steps:

[0071] Step i: Take 10.0ml of methanol solution of zinc nitrate hexahydrate (14.7mg / ml) in a round bottom flask, add 171.1μl of pyrrole, and stir magnetically (1000rpm) at 25°C for 10min.

[0072] Step ii. Add 10.0 ml of 2-methylimidazole in methanol (8.1 mg / ml) to the solution in step i, and continue stirring for 30 min.

[0073] Step iii. Add 20.0 ml of dextran aqueous solution (50.0 mg / ml) to the solution in step ii, continue stirr...

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Abstract

The invention discloses a hybrid nanoparticle used for photoacoustic imaging and photothermal therapy and its preparation method and application, and relates to the fields of materials and medicine. The hybrid nanoparticle has a core-shell structure and is composed of hydrophobic porous ZIF‑8 The inner layer of the core-shell structure is composed of the shell and the polypyrrole core with photoacoustic imaging and photothermal effects, and the outer layer is composed of hydrophilic polysaccharides. In the present invention, zinc ions are coordinated with 2-methylimidazole to form porous ZIF-8, and pyrrole is encapsulated in the pores of ZIF-8, and then adding a stabilizer polysaccharide and an initiator in situ triggers pyrrole in ZIF-8. The voids and surfaces are aggregated to produce hybrid nanoparticles with good water solubility and biocompatibility for photothermal effect and photoacoustic imaging. The preparation method of the invention is simple, high in efficiency and low in cost, and at the same time, the prepared hybrid nanoparticle has high photothermal conversion efficiency, and has broad application prospects in the field of tumor diagnosis and treatment integration.

Description

technical field [0001] The invention relates to the fields of materials and medicine, in particular to a hybrid nanoparticle for photoacoustic imaging and photothermal therapy, a preparation method and application thereof. Background technique [0002] Cancer treatment is one of the main methods to improve human health. At present, the clinical methods used to treat tumors mainly include surgical treatment and chemotherapy. Surgical treatment cannot completely eliminate tumor cells, and the possibility of recurrence is very high; chemotherapy will have many Side effects, including nephrotoxicity, neurotoxicity, etc. Photothermal therapy is a non-invasive, controllable targeting, and directional treatment with few side effects. After the photothermal agent is enriched in the tumor site, it converts light energy into heat energy under the irradiation of near-infrared light, and uses heat to kill tumor cells. So as to achieve the effect of tumor ablation. Photothermal therapy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22A61K41/00A61K9/51A61K47/22A61K47/36A61P35/00B82Y5/00B82Y20/00B82Y30/00B82Y40/00
CPCA61K9/5015A61K9/5036A61K9/5073A61K41/0052A61K49/225A61P35/00B82Y5/00B82Y20/00B82Y30/00B82Y40/00A61K2300/00
Inventor 窦红静胡强强
Owner SHANGHAI JIAOTONG UNIV
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