A long collagen fiber with natural structure and its preparation method and application

Abstract

The invention discloses a long collagen fiber with a natural structure and its preparation method and application. The spinning liquid containing PEG4000 and collagen is squeezed into a coagulation bath for wet spinning, collected by a rotating receiving device, and can be prepared. Collagen long fibers with different diameters can reach more than 100cm in length; at the same time, collagen long fibers with better chemical stability and mechanical properties can be obtained through post-processing, and the long collagen fibers can be used to bionically construct tissue engineering repair materials for nerve , blood vessels, tendons, ligaments and other tissue repairs with linear matrix characteristics, and can also be used for cartilage tissue repair. The preparation method is simple and easy to operate, can protect the structure of the collagen fiber from damage, retain its good biocompatibility, and can be industrialized.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a collagen long fiber with a natural structure and a preparation method and application thereof. Background technique [0002] As one of the main components of the extracellular matrix of connective tissue, collagen is often used as a scaffold material for tissue engineering. Due to its good biocompatibility and degradability, it can build an extracellular matrix microenvironment, which is conducive to cell adhesion and proliferation, and can induce the differentiation of bone marrow mesenchymal stem cells, showing certain biological activity and functionality. , so collagen, as an important biomaterial, is widely used in many clinical fields and has high practical application value. [0003] Many tissues in the human body, such as tendons, nerves, blood vessels, etc., are assembled from highly oriented microfibrous structural units, showing certain linear array matrix charac...

AI Technical Summary

Problems solved by technology

In existing reports, most collagen-based materials are in the form of block gels, microspheres, sponge membranes, etc. The collagen fibers in the materials do not have the characteristics of orderly arrangement, which affects their ability to repair and regenerate tissue defects. However, the advantages of collagen-based materials cannot be fully reflected; even if collagen fibers with ordered arrangement characteristics are prepared, there are still problems such as too short length, damage to the natural structure of collagen fibers, high cost, and difficulty in industrialization, which limits the production of collagen fibers. Application of Base Materials

[0004] For the repair of cartilage tissue, due to its lack of blood supply and undifferentiated cells, it is more difficult to repair damaged cartilage. In the current cartilage repair technology, it is usually necessary to add additional growth factors; if pure collagen scaffolds are used, it will also There are problems such as insufficient mechanical strength and excessive metabolic rate. It is often necessary to combine collagen materials with other high-strength materials. To some extent, the mechanical strength of the material can be partially improved, but the characteristic structure of collagen is often destroyed, making it loss of good biological properties

Images