A long-acting anticoagulant antibacterial coating for extracorporeal membrane oxygenation device (ecmo) and preparation method thereof

Abstract

The invention discloses a long-term anti-freezing antibacterial coating for extracorporeal membrane oxygenation (ECMO) device and a preparation method of the long-term anti-freezing antibacterial coating. The method comprises the following steps: (1) mixing an anti-freezing functional monomer, an antibacterial functional monomer and a film formation agent, and performing a reaction in a mode of free radical polymerization for 10-15 hours at 60-80 DEG C so as to obtain an anti-freezing antibacterial polymer; and (2) mixing the anti-freezing antibacterial polymer with a solvent, so as to obtainthe long-term anti-freezing antibacterial coating. The invention designs the coating with long-term anti-freezing and antibacterial functions simultaneously, and antifouling and sterilization functions can be well combined. With the combination of two functions, an effect of reducing risks of bacterium infection for a long time can be achieved. By reasonably selecting and controlling introductionof antibacterial functional components, the anti-freezing function of the coating can be well maintained.

Description

technical field [0001] The invention belongs to the technical field of biomedical new materials and devices, and in particular relates to a long-acting anticoagulant antibacterial coating for an extracorporeal membrane oxygenation device (ECMO) and a preparation method thereof. Background technique [0002] For medical devices that need long-term contact with blood, preventing the formation of thrombus and bacterial infection is a very key technical challenge. Although the use of drugs such as heparin and antibiotics can reduce certain risks, they still cannot meet the clinical needs. The reasons are as follows . [0003] On the one hand, in blood-contact devices, once blood touches the device surface, platelets and fibrinogen adhere to the surface of the material, and after activation, blood cells will be fixed by fibrin cross-linking to form a thrombus. Blood clots block blood vessels and can cause serious illness or even death. On the other hand, bacteria adhere to the ...

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Problems solved by technology

However, because the coating cannot be perfect, once the bacteria attach to the antifouling surface, the bacteria grow and multiply from one point to a large area, and finally form a biofilm, which shows that the pure antifouling coating is not suitable for long-term use medical instruments

On the other hand, a simple coating with antibacterial properties is difficult to hinder the adhesion of bacteria, especially the adhesion of dead bacteria.

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