Marker gene for clinical risk assessment of preeclampsia and application of marker gene

Abstract

The present invention discloses a marker gene for clinical risk assessment of preeclampsia and an application of the marker gene, and belongs to the technical field of medicine. Placenta tissue specimens of preeclampsia patients and normal pregnant women are used as research objects, RNA and proteins in trophoblast cells of placental tissues are extracted, at the same time, autophagy changes of the trophoblast cells in the preeclampsia are determined, and a role of ASPP2 in regulating the autophagy of the trophoblast cells is determined. The ASPP2 is clearly defined as a key target gene for early warning and diagnosis of the preeclampsia. The protein material is from the placenta, sample acquisition is simple and convenient, and the marker gene has no trauma to the patients, is generally accepted, has relatively strong promotion and implementation, and has extremely great application value in early diagnosis and risk assessment of the preeclampsia.

Description

technical field [0001] The invention belongs to the field of medical technology, and in particular relates to a marker gene for clinical risk assessment of preeclampsia and its application. Background technique [0002] Preeclampsia (Preeclampsia, PE) is one of the most common complications of pregnancy. It is a unique and common placental disease in pregnancy with the main pathological feature of placental dysfunction due to changes in the internal environment of pregnant women. According to reports, the incidence rate of PE in China is 9.4-10.4%, and it is 7.5-12.8% in foreign countries. The number of maternal deaths caused by it accounts for about 10.5-16.8% of the total number of pregnancy-related deaths, and it is the second largest cause of maternal deaths. . And since the implementation of my country's second-child policy in 2016, the national maternal mortality rate has increased by 30.6% over the same period last year, showing a trend of increasing year by year. I...

AI Technical Summary

Problems solved by technology

The explanation for preeclampsia caused by the elevated autophagy level of trophoblasts is that the autophagy function of trophoblasts is impaired, which leads to the low ability of trophoblasts to remove damaged organelles and excess protein, which causes them to replace spiral artery endothelial cells and degrade vascular smooth muscle and elasticity On the other hand, because the autophagy activity of trophoblasts is too strong, the trophoblasts die excessively, and the ability to invade the spiral arterioles is weakened, thus accelerating the process of preeclampsia

Images