Chimeric nucleic acid molecule used for immunoregulation, and application of chimeric nucleic acid molecule

Abstract

The invention relates to a chimeric nucleic acid molecule used for immunoregulation, and application of the chimeric nucleic acid molecule. Specifically, the chimeric nucleic acid molecule comprises aoligonucleotide with a CpG motif and an aptamer capable of resisting a lymphocyte activationgene 3 (LAG-3), a synergetic effect capable of activating toll-like receptor 9 (TLR9) can be generated, thechimeric nucleic acid molecule can be used to initiate systemic immune responses, and a disease treatment effect is improved.

Description

technical field [0001] The present application relates to chimeric nucleic acid molecules and their applications for immune modulation. Background technique [0002] T cells express inhibitory receptors (called immune checkpoint molecules), which suppress T cell responses. Examples of immune checkpoint molecules include programmed cell death protein 1 (PD-1), lymphocyte activation gene 3 (LAG-3), and cytotoxic T lymphocyte-associated protein 4 (CTLA-4). These immune checkpoint molecules are often activated in cancer, leading to suppressed anti-tumor immune responses. [0003] T cells also express stimulatory receptors, which activate the innate immune response. Examples of stimulatory receptors include Toll-like receptors (TLRs), which are activated by unmethylated cytosine-guanosine dinucleotide (CpG) motifs embedded in certain flanking sequences. [0004] In cancer treatment, there are still many patients who do not respond well to existing drugs. One possible reason is...

AI Technical Summary

Problems solved by technology

[0004] In cancer treatment, there are still many patients who do not respond well to existing drugs. One possible reason is that the immune response of these patients is suppressed so that effective treatment cannot be achieved

Images