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Composition for enhancing radiation-induced abscopal effect including LAG-3 inhibitor and PD-1 inhibitor
Pending
US20260191955A1
Lymphocyte
Radical radiotherapy
Disclosed herein is a composition for enhancing an abscopal effect of
radiation
, including a
lymphocyte
activation
gene
-3 (
LAG
-3) inhibitor and a
programmed cell death
protein
-1 (PD-1) inhibitor. One aspect relates to a method of enhancing an abscopal effect of
radiation
by co-administering a composition including an
LAG
-3 inhibitor and a PD-1 inhibitor in conjunction with radiotherapy in the treatment of
cancer
(e.g., triple-negative
breast cancer
).
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Owner:
SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
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