This invention discloses a targeted
adjuvant influenza vaccine composition for
atrial fibrillation patients with atrial
fibrosis. The
vaccine antigen components are selected from the surface antigens of currently prevalent influenza
virus strains, such as
hemagglutinin (HA) and
neuraminidase (NA). High-purity influenza
virus antigens are prepared through
cell culture or
recombinant DNA technology. For example, influenza
virus is cultured using Madin-Darby
canine kidney (MDCK) cells, and purified through
centrifugation,
filtration, and
chromatography to obtain high-purity HA and NA antigens. After injection into the
human body, the influenza virus antigens (HA and NA) are taken up and processed by
antigen-presenting cells (such as macrophages and dendritic cells). The
antigen-presenting cells present
antigen peptides to T lymphocytes and B lymphocytes, activating a specific immune response. B lymphocytes differentiate into
plasma cells with the help of T lymphocytes, producing specific antibodies that recognize and bind to the influenza virus, preventing it from infecting host cells and thus preventing influenza virus infection.