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Amantadine organic acid ion salt as well as preparation method and application thereof

An organic acid ion, amantadine technology, applied in the field of amantadine organic acid ion salt and preparation thereof, can solve the problems of strong toxicity, limited viral action, etc., and achieves the promotion of body absorption, good water solubility, and synthetic steps. easy effect

Pending Publication Date: 2020-06-26
珠海中科先进技术研究院有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In summary, although organic acids have low toxicity, they have a limited effect on viruses, and amantadine has a good inhibitory effect on viruses, but it is highly toxic

Method used

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  • Amantadine organic acid ion salt as well as preparation method and application thereof
  • Amantadine organic acid ion salt as well as preparation method and application thereof
  • Amantadine organic acid ion salt as well as preparation method and application thereof

Examples

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Embodiment 1

[0038] The test result of the ionic salt that embodiment 1 makes is as figure 1 shown, from figure 1 It can be seen that the ionic salt prepared in Example 1 of the present invention has a cell survival rate of over 50% even at a concentration of 100 μg / mL, therefore, it has low toxicity. The test conditions of the ionic salt samples prepared in other examples were similarly designed, and similar effects were also achieved. Even at 100 μg / mL, the cell survival rate can reach more than 50%.

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Abstract

The invention discloses amantadine organic acid ionic salt as well as a preparation method and the application thereof. The ionic salt comprises anions and cations. The precursors of the anions are organic acids, and precursors of the cations are amantadine. The amantadine organic acid ionic salt provided by the embodiment of the invention not only has pharmacological properties (antiviral and bacteriostatic properties and the like) of amantadine and an organic acid precursor, but also has good water solubility; and damage to organs caused by poor water solubility of adamantane in the oral administration process is avoided.

Description

technical field [0001] The invention relates to the technical field of drug synthesis, in particular to an amantadine organic acid ion salt and a preparation method and application thereof. Background technique [0002] Viruses are non-cellular parasitic living organisms composed of nucleic acid molecules and proteins. Due to the strong reproductive capacity of viruses, once infection occurs, systemic poisoning symptoms such as fever, headache, and cough, as well as virus hosts and invasion will appear. Local symptoms (diarrhea, rash, liver function damage, etc.) caused by inflammatory damage to tissues and organs. Symptoms vary depending on the virus, and some viruses can also damage the myocardium, causing viral myocarditis. Therefore, antiviral drugs are usually required. [0003] Amantadine, also known as tricyclic decylamine, is a commonly used antiviral drug, which is usually prepared by reacting adamantane with urea after bromination. It was used to inhibit influen...

Claims

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Application Information

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IPC IPC(8): C07C211/38C07C209/00C07C51/41C07C65/10C07C63/08C07C65/21C07C57/44C07C65/03A61K31/13A61K31/60A61K31/192A61P31/16A61P31/04A61P31/10
CPCC07C211/38C07C65/10C07C63/08C07C65/21C07C57/44C07C65/03A61P31/16A61P31/04A61P31/10C07C2603/74
Inventor 张嘉恒袁菊懋王岩闫修瑜陈正件李志超孔晶张晃淳
Owner 珠海中科先进技术研究院有限公司
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