Novel method for synthesizing 1-bromo-2,2-dimethoxypropane

A technology of dimethoxypropane and dichloromethane, which is applied in the field of biomedical intermediates, can solve the problems of difficult product purification, dangerous products, and low yield, and achieve easy purification, simple reaction operation, and improved reaction yield. Effect
CN111348992AInactive Publication Date: 2020-06-30TIANJIN QUANHECHENG TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN QUANHECHENG TECH
Publication Date
2020-06-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of biomedical intermediates, and provides a novel method for synthesizing 1-bromo-2,2-dimethoxypropane, wherein the method comprises the following steps: S1, bromination reaction: dissolving acetone in dichloromethane, preheating to 65 DEG C, adding bromine, controlling the temperature at 65-75 DEG C, and carrying out a reaction for 11-13 h to obtain 1-bromoacetone; S2, carrying out an up-protection reaction: dissolving 1-bromoacetone in methanol, adding trimethyl orthoformate and concentrated hydrochloric acid, and carrying out a reaction for 2-3 hto obtain 1-bromo-2,2-dimethoxypropane. By means of the technical scheme, the problems that in the prior art, hazardous materials are used in a method for synthesizing 1-bromo-2,2-dimethoxypropane, the yield is low, and a product is difficult to purify are solved.
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Description

technical field

[0001] The invention belongs to the technical field of biomedical intermediates, and relates to a new method for synthesizing 1-bromo-2,2-dimethoxypropane. Background technique

[0002] 1-Bromo-2,2-dimethoxypropane is an important biomedical intermediate, which can be widely used in the synthesis of various drugs. It has a small molecular weight and unique structure, and can be derived from a variety of downstream products. use. At present, the method for synthesizing 1-bromo-2,2-dimethoxypropane has the following defects: (1) involves the use of dangerous goods, such as phosphorus tribromide, concentrated sulfuric acid, etc.; (2) the reaction yield is low, Generally no more than 40%; (3) the product is difficult to purify; the manufacturers of 1-bromo-2,2-dimethoxypropane are very few, and the price is expensive, which seriously hinders the development of its downstream products and its application in the field of biomedicine further development. Content...

Claims

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