Cancer kit containing monoclonal antibody of specific binding ROS1

A monoclonal antibody, species-specific technology, applied in the direction of antibodies, specific peptides, anti-tumor drugs, etc., can solve the problem of no relevant reports on monoclonal antibodies, achieve inhibition of tumor cell growth, good binding specificity, and good application prospects Effect
CN111440241AActive Publication Date: 2020-07-24GUANGDONG CELL BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGDONG CELL BIOTECHNOLOGY CO LTD
Publication Date
2020-07-24

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Abstract

The present invention relates to a cancer kit containing a monoclonal antibody of specific binding ROS1. The monoclonal antibody is obtained by taking an ROS1 kinase domain obtained by screening as anantigen and immunizing a mouse. The antibody has the relatively good binding specificity, and it is verified that the antibody has the function of inhibiting the growth of tumor cells, so that the kit has the relatively good application prospect.
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Description

technical field

[0001] The present invention relates to the field of biology, and more specifically relates to a cancer kit comprising a monoclonal antibody specifically binding to ROS1. Background technique

[0002] ROS1 is an oncogene sequence that can be fused with the gag gene, and has certain tumorigenicity after fusion. The wild-type ROS1 gene is located in the q12 region of chromosome 6. It encodes 2347 amino acids with a molecular weight of 259kDa. The encoded protein is a transmembrane tyrosine kinase receptor protein, which consists of three parts: tyrosine kinase region, transmembrane region and extracellular region containing glycosylation site. The N-terminal 1861 amino acids constitute the extracellular region, the transmembrane region consists of about 1882 amino acids, and the C-terminal 464 amino acids constitute the cytoplasmic region. The membrane region consists of three YWTD domains folded into three β-helical structures interspersed in nine type III ...

Claims

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