Fever cooling patch gel and preparation method thereof

Abstract

The present invention relates to fever cooling patch gel, a preparation method of the gel. The fever cooling patch gel contains macromolecules and a liquid dispersion medium; the fever cooling patch gel is characterized in that a gel layer contains urea, and the urea content is greater than the urea solubility at 37.5 DEG C; and colloidal particles or the macromolecules can be dispersed or dissolved in the liquid dispersion medium to form the gel. The gel prepared by the method is stable in quality, convenient for continuous production and stable in product quality after being applied to a fever cooling patch, and the problems of aggravation, cough, throat inflammation and the like cannot be caused.

Description

technical field [0001] The invention relates to a gel for cooling plasters and a preparation method thereof. Background technique [0002] Most of the gels used in the existing antipyretic patches are composed of water and polymers, and the heat is taken away by the evaporation of water to achieve the purpose of cooling. In order to achieve a better cooling effect, it is explored to add heat-absorbing agents , such as a preparation method of intelligent children's antipyretic patch, patent number: 2016102500843, urea has a high solubility in heat-absorbing agents and absorbs more heat, so it has become the first choice for adding. However, due to the high solubility of urea, as the temperature increases Changes in the amount of urea precipitation and dissolution are relatively large, so in actual production, there is the problem of urea precipitation during the cooling gel process, resulting in the inconsistency of the content of urea in the upper, middle and lower layers of...

AI Technical Summary

Problems solved by technology

[0002] Most of the gels used in the existing antipyretic patches are composed of water and polymers, and the heat is taken away by the evaporation of water to achieve the purpose of cooling. In order to achieve a better cooling effect, it is explored to add heat-absorbing agents , such as a preparation method of intelligent children's antipyretic patch, patent number: 2016102500843, urea has a high solubility in heat-absorbing agents and absorbs more heat, so it has become the first choice for adding. However, due to the high solubility of urea, as the temperature increases Changes in the amount of urea precipitation and dissolution are relatively large, so in actual production, there is the problem of urea precipitation during the cooling gel process, resulting in the inconsistency of the content of urea in the upper, middle and lower layers of the prepared gel, which makes the prepared gel The quality of the antipyretic stickers is not consistent, which brings troubles to mass production

[0003] At the same time, the antipyretic patch prepared is sold to pharmacies rather than direct users, so there is a storage problem. It is found that the antipyretic patch with urea also has quality changes during the storage process, and even pharmacies have reactions. The cooling effect However, the antipyretic patch with urea has received the most complaints. The reason is that the user’s condition has worsened after using the antipyretic patch with urea. It was originally a mild fever without cough and throat inflammation. After using this product, it appeared cough and throat inflammation, which brings difficulties to the promotion of functional antipyretic patches with better cooling effect