Pharmaceutical composition with synergistic hypoglycemic effect and application of pharmaceutical composition
A composition and technology for lowering blood sugar, which is applied in the field of medicine, can solve the problem of lowering blood sugar, and has not yet used cinnamon aldehyde and kaempferol to form a composition, so as to achieve a good effect of lowering blood sugar
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Embodiment 1
[0036] Embodiment 1 cinnamon aldehyde and kaempferol single use and the influence of joint oral administration on blood sugar of normal Kunming mice
[0037] Take 20 male Kunming mice of SPF grade, body weight 29-32g, free to eat and drink, give common nutritional feed, and place in constant temperature and humidity (temperature: 21-25°C, humidity: 45-65%), alternate cycle for 12 hours Raise under the condition of light, and adapt to feed for 1 week. Before the experiment, they were randomly divided into 4 groups, 5 rats in each group, fasted for 16 hours, and kept drinking water freely. Intragastric administration at the 12th hour of fasting, the dosage regimen is shown in Table 1:
[0038] Table 1 Dosage regimen of cinnamon aldehyde and kaempferol
[0039]
[0040] The result is as figure 1 As shown, the results show that both cinnamon aldehyde and kaempferol have a certain hypoglycemic effect when used alone, and when the dosage of cinnamon aldehyde and kaempferol is ...
Embodiment 2
[0041] The investigation of cinnamon aldehyde and kaempferol dosage ratio when embodiment 2 combined oral administration
[0042] Take 30 male Kunming mice of SPF grade, body weight 27-34g, free to eat and drink, give ordinary nutritious feed, and place in constant temperature and humidity (temperature: 21-25°C, humidity: 45-65%), alternate cycle for 12 hours Raise under the condition of light, and adapt to feed for 1 week. Before the experiment, they were randomly divided into 6 groups, 5 rats in each group, fasted for 16 hours, and kept drinking water freely. Intragastric administration at the 12th hour of fasting, the dosage regimen is shown in Table 2:
[0043] The dosing regimen of table 2 cinnamon aldehyde and kaempferol
[0044]
[0045] After the 16th hour of administration, blood was taken from the tail vein, and blood glucose changes in mice were detected by Aike Jingyi blood glucose meter (purchased from Hangzhou Aikang Biotechnology Co., Ltd., article number X...
Embodiment 3
[0054] Example 3 The investigation of the optimal hypoglycemic ratio of cinnamaldehyde and kaempferol combined oral administration
[0055] Take 156 male Kunming mice of SPF grade, body weight 28-34g, free to eat and drink, give common nutritional feed, and place in constant temperature and humidity (temperature: 21-25°C, humidity: 45-65%), alternate cycle for 12 hours Raise under the condition of light, and adapt to feed for 1 week. Before the experiment, they were randomly divided into 26 groups, 6 rats in each group, fasted for 16 hours, and kept drinking water freely. Intragastric administration at the 12th hour of fasting, the dosage regimen is shown in Table 4:
[0056] The administration scheme of table 4 cinnamon aldehyde and kaempferol
[0057]
[0058] After the 16th hour of administration, blood was taken from the tail vein, and blood glucose changes in mice were detected by Aike Jingyi blood glucose meter (purchased from Hangzhou Aikang Biotechnology Co., Ltd....
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