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Chiral electrochemical sensor and application thereof

An electrochemical and sensor technology, applied in the field of chiral electrochemical sensors, can solve the problems of short service life, poor enantiomeric discrimination ability, and incomplete discrimination, and achieve high sensitivity, long service life, and high discrimination. Effect

Active Publication Date: 2020-07-31
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention aims to solve the technical problems of poor enantiomer discrimination ability (small electrical signal difference), incomplete discrimination, in-situ simultaneous discrimination, and extremely short service life (within 2 times) in current chiral electrochemical sensors, and provides a A chiral electrochemical sensor based on intrinsic chiral nanocrystals and its application

Method used

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  • Chiral electrochemical sensor and application thereof
  • Chiral electrochemical sensor and application thereof
  • Chiral electrochemical sensor and application thereof

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preparation example Construction

[0034] The preparation process of the chiral electrochemical sensor of the present invention is as follows:

[0035] Design and synthesis of high-index noble metal nanocrystals with intrinsic chirality:

[0036] (1) Prepare cetylpyridinium chloride (CPC)-protected Au cube, octahedron, and dodecahedron seeds using the method previously proposed by our research group. The general process is to first synthesize CTAB-protected 1.5nm seeds by sodium borohydride reduction method Gold seeds; on this basis, with the assistance of silver ions, AA was reduced to synthesize gold nanorods; after the secondary growth of gold nanorods, chloroauric acid was added to oxidize and corrode them into gold seeds protected by CPC. Gold seeds protected by CPC can be grown into Au cube, octahedron, and dodecahedron seeds by regulating the growth kinetics and thermodynamics under the protection of CPC.

[0037] (2) According to literature [Lee, H.-E., Ahn, H.-Y., Mun, J., Lee, Y.Y., Kim, M., Cho, N.H...

Embodiment 1

[0040] Example 1: Preparation of cubic Au seeds: 1.5nm gold seeds protected by CTAB were synthesized by sodium borohydride reduction at 30°C; with the assistance of silver ions, CTAB was used as a protective agent, and the weak reducing agent AA was reduced to form gold nanorods; After the secondary growth of gold nanorods, chloroauric acid is added to oxidize and corrode them into gold seeds protected by CPC; CPC is used as a protective agent, and the crystal face inducer Br - , CPC-protected gold seeds, and AA as a reducing agent to finally obtain CPC-protected gold cube seeds.

[0041] Preparation of cysteine-induced intrinsic chiral gold nanocrystals: Add 0.8mL 100mMCTAB and 0.2mL 10mM HAuCl to 3.95mL water successively 4 , 0.475mL 100mM AA as a reducing agent, 50μL cubic CPC gold seeds, incubated for 5min, added 50μL 10μM L-cysteine, and grown at 30°C for 2h. prepared as image 3 Medium helical chiral gold nanoparticles.

[0042] Preparation of intrinsic chiral electro...

Embodiment 2

[0043] Example 2: Preparation of cubic Au seeds: 1.5nm gold seeds protected by CTAB were synthesized by sodium borohydride reduction at 30°C; with the assistance of silver ions, CTAB was used as a protective agent, and the weak reducing agent AA was reduced to form gold nanorods; After the secondary growth of gold nanorods, chloroauric acid is added to oxidize and corrode them into gold seeds protected by CPC; CPC is used as a protective agent, and the crystal face inducer Br - , CPC-protected gold seeds, and AA as a reducing agent to finally obtain CPC-protected gold cube seeds.

[0044] Preparation of cysteine-induced intrinsic chiral gold nanocrystals: Add 0.8mL 100mMCTAB and 0.2mL 10mM HAuCl to 3.95mL water successively 4 , 0.475mL 100mM AA as a reducing agent, 100μL cubic CPC gold seeds, incubated for 5min, added 50μL 10μM D-cysteine, and grown at 30°C for 2h. prepared as Figure 4 Right-handed chiral gold nanoparticles.

[0045] Preparation of intrinsic chiral electro...

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Abstract

The invention relates to a chiral electrochemical sensor based on intrinsic chiral nanocrystals and application thereof, belongs to the technical field of electrochemical sensors, and solves the technical problems in the existing chiral electrochemical sensor that the enantiomer distinguishing capacity is poor, complete distinguishing is not achieved, in-situ simultaneous distinguishing cannot beachieved, and the service life is extremely short. The chiral electrochemical sensor comprises an electrode and intrinsic chiral nanocrystals fixed on the surface of the electrode. The intrinsic chiral nanocrystal is proposed for the first time to be used for constructing the chiral electrochemical sensor, the chiral interface modified by the chiral nanocrystal material has an intrinsic chiral recognition capability, and the difference is generated between the chiral interface modified by the chiral nanocrystal material and a non-covalent bond acting force between electrode chiral interfaces.Targeted chiral molecular isomers can be truly distinguished by the non-covalent bond acting force and the molecular chiral group associated party. The electrochemical chiral sensor can be used for identifying amino acids in foods, active ingredients in chiral medicines and chiral isomers in human bodies.

Description

technical field [0001] The invention relates to the technical field of electrochemical sensors, in particular to a chiral electrochemical sensor based on intrinsic chiral nanocrystals and its application. Background technique [0002] Most of the existing chiral electrochemical sensors are constructed using chiral selective reagents. Researchers have successfully constructed different chiral electrochemical sensors using a variety of chiral selective reagents. According to the different interaction mechanisms between chiral selective reagents and chiral enantiomers, electrochemical chiral recognition can be divided into: host-guest recognition, chiral reagent transfer recognition, chiral biomacromolecule adsorption recognition, and molecular imprinting recognition. The essence of all the above-mentioned chiral recognition is that the chiral molecule participates as the main body, and then interacts with the target chiral molecule. The chirality of the prepared chiral elect...

Claims

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Application Information

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IPC IPC(8): G01N27/327G01N27/48
CPCG01N27/3278G01N27/3277G01N27/48
Inventor 牛文新李风华贾菲吴峰霞鲍海波
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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