Cardiac surgery autologous pericardium patch processor and rapid anti-calcification processing method

A technology of processor and pericardium, which is applied in the fields of prosthesis, medical science, tissue regeneration, etc., can solve the problems of loss of activity of autologous pericardium, difficulty in surgical suturing and pruning, uneven pericardium curling, etc., and achieves low manufacturing cost and good prevention Calcification effect, effect of preventing calcification failure

Active Publication Date: 2020-08-07
QINGDAO WOMEN & CHILDREN HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, autologous pericardial slices treated with glutaraldehyde solution lose their activity, and are prone to secondary calcification and loss of function
At the same time, the commonly used glutaraldeh

Method used

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  • Cardiac surgery autologous pericardium patch processor and rapid anti-calcification processing method
  • Cardiac surgery autologous pericardium patch processor and rapid anti-calcification processing method
  • Cardiac surgery autologous pericardium patch processor and rapid anti-calcification processing method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1 is compared with comparative example 1, * PΔ P<0.01 The difference between the two was statistically significant.

[0042] It can be seen from Table 1 that the degree of calcification of the autologous pericardial slices processed by the method of the present invention is significantly reduced by visual observation.

[0043] It can be seen from Table 2 that the calcium content of the autologous pericardial slices treated by the present invention was significantly reduced after subcutaneous embedding for 60 days.

[0044] It can be seen that the rapid anti-calcification treatment method for autologous pericardial patch designed by the present invention successively passes through the steps of smoothing and shaping, polyethylene glycol tanning, and magnesium ion impregnation, and each step is sequentially connected and coordinated, so that the prepared autologous Pericardial patch has better anti-calcification effect.

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Abstract

The invention discloses a rapid anti-calcification processing method of a cardiac surgery autologous pericardium patch. The method comprises the following steps: (1) soaking the dirty layer of the autologous pericardium patch, which is taken down, by using a glutaraldehyde solution, and flattening by pressing; (2) soaking the pericardium patch in a first processing solution prepared from polyethylene glycol and a tris-hydrochloric acid buffer solution, and then rinsing with warm normal saline; (3) putting the pericardial patch into a second processing solution prepared from warm normal salineand a magnesium chloride solution, soaking and rinsing; and (4) trimming into a required shape to obtain the autologous pericardium patch for a heart defect repair operation. The method sequentially comprises the steps of flattening and shaping, polyethylene glycol tanning, magnesium ion impregnation and the like. All the steps are sequentially connected and cooperatively matched, so that the prepared autologous pericardium patch has a good anti-calcification effect, animal experiments and clinical application can effectively prevent the autologous pericardium patch from calcifying and losingpower after cardiac surgery, and the operation is simple and rapid.

Description

technical field [0001] The invention relates to an autologous pericardial patch processor in cardiac surgery, and a treatment method for preventing autologous pericardial calcification in combination with the use of the autologous pericardial patch processor. Background technique [0002] Patch materials are often used in heart repair in cardiac surgery, and autologous fresh pericardium slices are the most ideal material because they are cheap and easy to obtain. However, due to the softness of the fresh pericardium, it is difficult to clamp during surgical suturing, so it is often necessary to treat it with glutaraldehyde solution to make it shape so as to facilitate clamping and suturing. However, autologous pericardial slices treated with glutaraldehyde solution lose their activity, and are prone to secondary calcification and loss of function. At the same time, the commonly used glutaraldehyde solution to treat the pericardium is mostly soaked in a basin-shaped vessel, ...

Claims

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Application Information

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IPC IPC(8): A61L27/36
CPCA61L27/3604A61L27/3641A61L27/3687A61L2430/20A61L2430/40
Inventor 武钦石磊邢泉生
Owner QINGDAO WOMEN & CHILDREN HOSPITAL
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