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A crystallization system and method for enhancing the molecular crystallization process

A molecular crystallization and crystallization technology, applied in the direction of solution crystallization, crystallization adjustment/control, etc., can solve the problems of difficult to achieve supersaturation of crystallization solution concentration, limit the success rate of molecular crystallization, etc., to shorten the induction time, precise and controllable crystallization process, Wide range of effects

Active Publication Date: 2021-07-16
DALIAN UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for some high value-added samples, the crystallization solution concentration is difficult to reach supersaturation, which severely limits the success rate of molecular crystallization

Method used

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  • A crystallization system and method for enhancing the molecular crystallization process
  • A crystallization system and method for enhancing the molecular crystallization process
  • A crystallization system and method for enhancing the molecular crystallization process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Prepare the micro crystallizer by 3D printing technology, and use the method a in step 1 to process the crystallizer for use. Dissolve 1.4g of NaCl in 20mL of deionized water, and prepare a stable and uniform solution at 25°C for use. Open the nitrogen inlet and outlet valves, exhaust the air in the crystallization system, and use the temperature and humidity controller to regulate the temperature in the system to 10-30°C and the humidity to 40-80%. Then use the droplet adding device to drop the configured crystallization solution in the charged concave well matrix of the microcrystallizer, and immediately turn on the high-voltage direct current power supply (connect the upper and lower electrode plates), adjust the voltage to 10kV, and make the crystallizer Static evaporation in a stable electric field for 24h, to obtain crystals such as image 3 .

Embodiment 2

[0032]Prepare the micro crystallizer by 3D printing technology, and use the method c in step 1 to process the crystallizer for use. Dissolve 13.6g of sodium acetate powder in 83.1g of glacial acetic acid solution to make acetic acid-sodium acetate buffer concentrate, take 6.5g of acetic acid-sodium acetate buffer concentrate and dissolve it in 1L of deionized water, stir well to obtain a pH value of 3.65 buffer for use. Subsequently, dissolve 300mg of lysozyme freeze-dried powder in 10mL of the above buffer, dissolve 0.5g of NaCl in 10mL of buffer as a crystallization agent, mix the two, add 0.6g of glycerol as an additive, and mix well Afterwards, the lysozyme solution was obtained for use. Open the nitrogen inlet and outlet valves, exhaust the air in the crystallization system, and use the temperature and humidity controller to regulate the temperature in the system to 10-30°C and the humidity to 40-80%. Then drop the above-mentioned crystallization solution into the charg...

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Abstract

The invention belongs to the technical field of crystallization and provides a crystallization system and method for strengthening molecular crystallization process. The crystallization system of the invention consists of a crystallizer, a nitrogen protection chamber at atmospheric pressure, a controllable electric field, dropwise addition of crystallization solution, a real-time monitoring system, and a temperature and humidity control system. In the present invention, the crystallizer has a matrix of micron-scale concave wells, and its charge properties are modulated, and then the regulation of the micro-electric field at the structure of the concave wells of the crystallizer is realized under an external electric field, so as to promote the directional movement of charged molecules and achieve crystallization solution local supersaturation, so as to realize the regulation of molecular crystallization behavior. The existence of an external electric field can significantly reduce the difficulty of the molecular crystallization process and enhance the controllability of the process. The crystallization system is simple to set up, low in cost, and the method is simple and easy to operate, and is applicable to the regulation of the crystallization process by various conditional parameters such as magnetic field, electric field, temperature, humidity, and pH.

Description

technical field [0001] The invention belongs to the technical field of crystallization, and in particular relates to a crystallization system and method for strengthening molecular crystallization process. Background technique [0002] As a low-energy, low-pollution, high-efficiency separation and solid product refining process, solution crystallization is widely used in food industry, pharmaceutical industry, biochemical industry, catalyst manufacturing and other fields. The traditional means of solution crystallization are mainly evaporation crystallization, cooling crystallization and extraction crystallization. However, they all have some limitations. For evaporative crystallization, the high temperature severely restricts the crystallization of heat-sensitive molecules; for low-concentration crystallization solutions, cooling crystallization requires high energy consumption and low yield, and extraction crystallization requires the addition of new components. , which n...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D9/02
CPCB01D9/0063
Inventor 贺高红袁志杰姜晓滨李甜甜肖武李祥村吴雪梅
Owner DALIAN UNIV OF TECH
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