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A SNP Molecular Marker Associated with Feed Conversion Efficiency in Pigs

A feed conversion efficiency and molecular marker technology, applied in the field of swine molecular marker screening, can solve problems such as difficulty in improving feed efficiency-related traits, and inability to directly measure feed efficiency, and achieve high sensitivity and good specificity.

Active Publication Date: 2021-09-17
赤峰家育种业科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In animal breeding programs, it is difficult to improve feed efficiency-related traits by direct selection because feed efficiency cannot be directly measured

Method used

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  • A SNP Molecular Marker Associated with Feed Conversion Efficiency in Pigs
  • A SNP Molecular Marker Associated with Feed Conversion Efficiency in Pigs
  • A SNP Molecular Marker Associated with Feed Conversion Efficiency in Pigs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: Genotyping Detection

[0035] (1) Integrating 16 batches of SNP microarray data from 4005 pigs of four breeds including Large White pig, Landrace pig, Duroc pig and Pietrain pig collected by the laboratory;

[0036] (2) Convert the raw data to Plink format (.ped / .map), and then use Plink software for preliminary quality control (--geno 0.1--maf 0.05--mind 0.1--chr 1-18,X). Use Beagle software to fill the data after the initial quality control, and then use Plink software for the second quality control (--geno 0.1--maf 0.05--mind 0.1), and finally there are 2013 individuals and 46505 SNPs for the whole Genome Association Analysis (GWAS).

Embodiment 2

[0037] Example 2: Application of MARC0045707 molecular marker typing method in pig feed conversion efficiency traits correlation analysis MARC0045707 molecular marker (see sequence listing SEQ ID NO: 1) and pig feed conversion efficiency traits correlation analysis:

[0038] The phenotypes used in the association analysis of genotypes and feed conversion efficiency traits mainly come from data collected in laboratories. Genome-wide association analysis (GWAS) was performed using the FarmCPU model in the rMVP package in the R statistical environment. The FarmCPU model uses a fixed effect model and a random effect model in a cycle. The specific models are as follows: (1) (2)y i = u i +e i , where y i Represents the trait observation value of the i-th individual, is the genotype of t possible association loci added to the model, b 1 , b 2 ,...,b t is the corresponding effect value of the possible association sites added to the model; S ij is the genotype of the jth gen...

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Abstract

The invention belongs to the technical field of pig molecular marker screening, and in particular relates to a SNP molecular marker related to pig feed conversion efficiency. The SNP molecular marker accession number is MARC0045707. By integrating 16 batches of SNP chip data collected by the laboratory, including 4005 pigs of the four breeds of Large White pig, Landrace pig, Duroc pig and Pietrain pig, the comparison pig reference The genotyping data is obtained from the genome sequence, and a SNP molecular marker related to the feed conversion efficiency of pigs is obtained. The nucleotide sequence of the SNP marker is shown in SEQ ID NO: 1, and the 51st base of the sequence is R is a mutation site, which is mutated from base A to base G, and the mutation site causes polymorphism in the nucleotides of the sequence shown; when the 51st nucleotide of the sequence described in SEQ ID NO: 1 is G, it is judged that the feed conversion efficiency of the pig is low.

Description

technical field [0001] The invention relates to the technical field of porcine molecular marker screening, in particular to a SNP molecular marker related to pig feed conversion efficiency and application thereof. The molecular marker of the invention can be used for auxiliary selection and prediction of pig feed conversion efficiency traits. Background technique [0002] Pork is an important meat source for humans, accounting for nearly 40% of the total meat consumed by the world's population. Feed costs account for the highest proportion of total production costs, ranging from 50% to 85% (Young J M, Cai W, Dekkers J CM. Effect of selection for residual feed intake on feeding behavior and daily feed intake patterns in Yorkshire swine[ J]. Journal of Animal Science, 2011, 89(3):639-647.). The key to reducing feed cost is to improve feed conversion ratio (FCR). Improving feed conversion efficiency can not only reduce feed consumption, agricultural costs and energy consumpt...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6888C12N15/11G16B20/20
CPCC12Q1/6888C12Q2600/124C12Q2600/156G16B20/20
Inventor 赵书红黄鑫刘小磊李新云尹立林许婧雅项韬马云龙唐振双朱猛进余梅
Owner 赤峰家育种业科技有限公司
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