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Application of protopanoxadiol in preparation of medicines

Protopanaxadiol, a technology for preparing drugs, applied in drug combinations, pharmaceutical formulas, antineoplastic drugs, etc., to achieve the effects of alleviating weight loss, improving physical fatigue, and good dose-effect relationship

Inactive Publication Date: 2020-08-14
HAINAN ASIA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The Chinese invention patent application publication number 02146549.5 discloses a method for preparing high-purity 20(S)-protopanaxadiol, which discloses that 20(S)-protopanaxadiol is used to enhance the efficacy of anticancer drugs, reduce Toxicity of anticancer drugs, prevention and treatment of leukopenia caused by radiotherapy and chemotherapy, and enhancement of immune function of the body, but 20(S)-protopanaxadiol has the function of treating cancer fatigue

Method used

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  • Application of protopanoxadiol in preparation of medicines
  • Application of protopanoxadiol in preparation of medicines
  • Application of protopanoxadiol in preparation of medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0057] Embodiment 2: the toxicity test of PPD

[0058] 2.1 PPD oral acute toxicity test

[0059] According to the guiding principles, the acute toxicity observation of PPD was carried out by intragastric administration in mice and rats. Since the LD50 could not be measured, the maximum dosage was determined. Mice were administered intragastrically once, with a dose of 4g / kg, and no adverse reactions and deaths were found in animals; rats were administered intragastrically twice, with a cumulative dose of 4g / kg, and no adverse reactions and deaths were found, indicating that acute PPD Toxicity is very low.

[0060] 2.2 Oral long-term toxicity test in rats

[0061] In the long-term toxicity test of rats, PPD was administered to rats continuously for 12 weeks with 200mg / kg, 400mg / kg, and 800mg / kg. , hematology and blood biochemical examination, major organ coefficient compared with the control group were no significant difference. Gross and microscopic examination of each org...

Embodiment 3

[0065] Embodiment 3: PPD capsule preparation prescription and preparation method:

[0066] prescription:

[0067]

[0068] Crush PPD, pass through a 120-mesh sieve, mix with sucrose stearate S11, lactose, and micropowder silica gel in proportion, mix well, pass through a 100-mesh sieve, add 1% polyvinylpyrrolidone (K-30) ethanol solution to granulate , passed through a 20-mesh sieve, dried at 60°C, granulated, and filled into capsules. The PPD content is 25mg / capsule.

Embodiment 4

[0069] Embodiment 4: PPD tablet prescription and preparation method

[0070] prescription:

[0071]

[0072] The PPD is pulverized, passed through a 120-mesh sieve, mixed with lactose, microcrystalline cellulose, crospovidone and magnesium stearate in proportion, and fully mixed. Directly compressed into tablets, each tablet contains 25mg of PPD.

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Abstract

The invention discloses a new application of protopanoxadiol, and particularly relates to a new application of the protopanoxadiol serving as an active ingredient or a unique active ingredient in preparation of medicines for treating cancer fatigue. Animal experiment results show that the protopanoxadiol not only can obviously improve evaluation indexes of general conditions such as weight loss, mental state and diet condition of tumor-bearing chemotherapy mice in a cancer fatigue model, but also has an obvious treatment effect on physiological fatigue and psychological fatigue indexes relatedto cancer fatigue of the tumor-bearing chemotherapy mice. The technical scheme provided by the invention shows that the protopanoxadiol can improve the tumor microenvironment and the hematopoietic function of CRF mice. Acute toxicity and long-term toxicity tests also show that the protopanoxadiol is high in clinical medication safety, can be used for preparing drugs for treating cancer fatigue, and has important medicinal value.

Description

technical field [0001] The present invention relates to the application of a compound in medicine for treating cancer, in particular to the application of protopanaxadiol in medicine for treating cancer fatigue. Background technique: [0002] Cancer fatigue, also known as cancer-related fatigue (deficiency) or cancer-related fatigue (CRF) is a disturbing, persistent physical, emotional, and / or Or cognitive subjective fatigue and energy exhaustion, which interfere with daily life and function, run through the entire process of tumor occurrence, development, treatment and prognosis, and are the most common and painful symptoms of cancer patients. The incidence of cancer fatigue is extremely high in patients with malignant tumors. The main difference from general fatigue is that it cannot be relieved after rest, which greatly damages the quality of life and quality of life of patients. Therefore, CRF has attracted more and more people. focus on. Although the incidence of mali...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P35/00A61P39/00
CPCA61K31/575A61P35/00A61P39/00
Inventor 商铁存王豆豆郑望升蒋宇佳吕惠群姜二晨蔡泓薇
Owner HAINAN ASIA PHARM CO LTD
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