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A kind of polypeptide compound for treating polycystic ovary syndrome and its application

A technology for polycystic ovary syndrome, which is applied in the field of polypeptide compounds for the treatment of polycystic ovary syndrome and drugs for the treatment of polycystic ovary syndrome, can solve the problems of poor curative effect, reverse insulin resistance, and improve polycystic ovary syndrome Sign effect

Active Publication Date: 2021-05-28
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] PCOS patients with fertility requirements often need to use ovulation induction therapy to get pregnant. PCOS drug ovulation induction therapy has made great progress in the past 50 years, but some patients have poor efficacy of conventional methods, so the appropriate solution is ovulation induction key to healing

Method used

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  • A kind of polypeptide compound for treating polycystic ovary syndrome and its application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Three-week-old SD rats were selected to prepare polycystic ovary syndrome insulin resistance animal models, and drug intervention was performed on the successful model mice.

[0020] ELISA and other methods were used for detection, and statistical software SPSS19.0 was used for analysis to clarify the therapeutic effect and possible mechanism of the polypeptide Met-Trp-Trp-His-His-Met on polycystic ovary syndrome insulin resistance animal models.

[0021] 1. Materials

[0022] 1.1 Experimental animals

[0023] 120 3-week-old SPF female SD rats were raised in the Animal Center of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine. 25°C constant temperature (50% humidity) clean-grade breeding, without feeding vitamin products, 12h light and 12h dark cycle alternately.

[0024] 1.2 Main reagents

[0025] DHEA (Sigma Company), peptide Met-Trp-Trp-His-His-Met (Shanghai Sangong Synthetic), metformin (Shanghai Ziyi Co., Ltd.), blood glu...

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Abstract

The present invention relates to a polypeptide compound for treating polycystic ovary syndrome and application thereof, which has the amino acid sequence shown in SEQ ID NO.1. The polypeptide of the invention can improve polycystic ovary syndrome, is particularly suitable for regulating sexual cycle disorder caused by polycystic ovary syndrome, and can effectively reverse insulin resistance.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a medicine for treating polycystic ovary syndrome, especially a polypeptide compound for treating polycystic ovary syndrome and its application. Background technique [0002] Polycystic ovary syndrome (PCOS) is a common complex endocrine and metabolic disorder in women of childbearing age. ) is characterized by irregular menstrual cycles, infertility, hirsutism and / or acne, and is the most common female endocrine disease. [0003] At present, drug treatment of PCOS has replaced surgical treatment as the first-line treatment, and the purpose of treatment is mainly related to the fertility requirements of patients. Oral contraceptives (OCP) have been used as a traditional long-term treatment for women with PCOS, mainly used to protect the endometrium, adjust the menstrual cycle, and improve hirsutism and / or acne by reducing the androgen produced by the ovary. OCP ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/06A61K38/08A61P15/08A61P5/50A61P15/00
CPCA61K38/00A61P5/50A61P15/00A61P15/08C07K7/06
Inventor 韩亚光朱小琳韩亚鹏
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE