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Application of short peptide asp-his-tyr in preparation of medicine for treating polycystic ovary syndrome

An asp-his-tyr, polycystic ovary technology, applied in the field of biomedicine, can solve the problems of poor curative effect, achieve the effect of reversing insulin resistance and improving polycystic ovary syndrome

Active Publication Date: 2021-07-27
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] PCOS patients with fertility requirements often need to use ovulation induction therapy to get pregnant. PCOS drug ovulation induction therapy has made great progress in the past 50 years, but some patients have poor efficacy of conventional methods, so the appropriate solution is ovulation induction key to healing

Method used

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  • Application of short peptide asp-his-tyr in preparation of medicine for treating polycystic ovary syndrome

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Three-week-old SD rats were selected to prepare polycystic ovary syndrome insulin resistance animal models, and drug intervention was performed on the successful model mice.

[0019] ELISA and other methods were used for detection, and statistical software SPSS19.0 was used for analysis to clarify the therapeutic effect and possible mechanism of the short peptide Asp-His-Tyr on polycystic ovary syndrome insulin resistance animal models.

[0020] 1. Materials

[0021] 1.1 Experimental animals

[0022] 120 3-week-old SPF female SD rats were raised in the Animal Center of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine. 25°C constant temperature (50% humidity) clean-grade breeding, without feeding vitamin products, 12h light and 12h dark cycle alternately.

[0023] 1.2 Main reagents

[0024] Dehydroepiandrosterone (Sigma Company), short peptide Asp-His-Tyr (Shanghai Sangong Synthetic), metformin (Shanghai Ziyi Co., Ltd.), blood g...

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Abstract

The invention relates to the application of short peptide Asp-His-Tyr in the preparation of medicines for treating polycystic ovary syndrome. The short peptide Asp-His-Tyr of the present invention can improve polycystic ovary syndrome, is particularly suitable for regulating sexual cycle disorder caused by polycystic ovary syndrome, and can also effectively reverse insulin resistance.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of short peptide Asp-His-Tyr in the preparation of medicines for treating polycystic ovary syndrome. Background technique [0002] Polycystic ovary syndrome (PCOS) is a common complex endocrine and metabolic disorder in women of childbearing age. ) is characterized by irregular menstrual cycles, infertility, hirsutism and / or acne, and is the most common female endocrine disease. [0003] At present, drug treatment of PCOS has replaced surgical treatment as the first-line treatment, and the purpose of treatment is mainly related to the fertility requirements of patients. Oral contraceptives (OCP) have been used as a traditional long-term treatment for women with PCOS, mainly used to protect the endometrium, adjust the menstrual cycle, and improve hirsutism and / or acne by reducing the androgen produced by the ovary. OCP can reduce hyperandrogenism i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/06A61P15/08A61P5/50A61P5/00C07K5/093
CPCA61K38/06A61P5/00A61P5/50A61P15/08C07K5/0819
Inventor 朱小琳韩亚光韩亚鹏韩延华
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE