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Application of dihydroartemisinin in preparation of medicine for treating inflammation caused by virulence protein of streptococcus suis

A technology of dihydroartemisinin and Streptococcus suis, applied in the field of pharmacy

Inactive Publication Date: 2020-09-04
CHINA AGRI UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0005] However, so far, no studies have reported that dihydroartemisinin has the efficacy of treating diseases caused by Streptococcus suis

Method used

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  • Application of dihydroartemisinin in preparation of medicine for treating inflammation caused by virulence protein of streptococcus suis
  • Application of dihydroartemisinin in preparation of medicine for treating inflammation caused by virulence protein of streptococcus suis
  • Application of dihydroartemisinin in preparation of medicine for treating inflammation caused by virulence protein of streptococcus suis

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Embodiment

[0031] animal

[0032] 6-week-old female C57BL / 6 mice were raised in an experimental animal room with a constant temperature of 22°C and no specific pathogens, with a 12-hour light / dark cycle per day, free access to food and water, and an adaptation period of 2 weeks. The weight of the mice was about 25g at the beginning of the experiment . The mouse feed was maintenance feed, which was purchased from Beijing Huafukang Biotechnology Co., Ltd., and the drinking water was purified water. One week before the start of the experiment, the mice were randomly divided into 10 groups according to body weight, namely the control group, the MRP treatment group, the DhA treatment group, and the DhA+MRP treatment group. Cage three. For 6 consecutive days after the start of the test, 0.1 mL of olive oil dissolved in DhA was injected intraperitoneally into the DhA treatment group and the DhA+MRP treatment group (so that the DhA injection amount was 5 mg / kg·BW), and 0.1 mL of olive oil was ...

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Abstract

The invention provides application of dihydroartemisinin in preparation of a medicine for treating inflammation caused by virulence protein of streptococcus suis. The dihydroartemisinin can effectively relieve inflammatory response of a body caused by infection of the streptococcus suis, has a good treatment effect, and has theoretical research and clinical application values in the aspect of tissue damage caused by the streptococcus suis.

Description

technical field [0001] The present invention relates to the field of pharmacy. Specifically, the present invention relates to the application of dihydroartemisinin in the preparation of medicines for treating inflammation caused by virulence proteins of Streptococcus suis. Background technique [0002] Streptococcus suis is a zoonotic infectious disease caused by pathogenic Streptococcus suis. Pigs are the main host of Streptococcus suis, but those who are engaged in pig breeding and meat processing are susceptible groups. There is little transmission. The main clinical symptoms of Streptococcus suis are sepsis, meningitis and arthritis, etc., and can cause death in severe cases. The disease occurs in all countries in the world, especially in Asia, Europe and North America. In 2005, an outbreak of human Streptococcus suis in my country's Sichuan Province resulted in 215 human infections and 38 deaths. Streptococcus is an oval Gram-positive bacterium, which is divided into...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/357A61P31/04
CPCA61K31/357A61P31/04
Inventor 武振龙杨鹰孙开济
Owner CHINA AGRI UNIV
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