Multifunctional traditional Chinese medicinal anticancer nano-carrier and application thereof

A nano-carrier and multi-functional technology, which can be used in anti-tumor drugs, drug combinations, and pharmaceutical formulations, and can solve problems such as cumbersome steps, complicated methods, and difficult control of dispersion

Active Publication Date: 2016-09-07
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the composite nano-drug carrier needs to first prepare graphene oxide whose dispersion is difficult to control, and then graft transferrin th...

Method used

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  • Multifunctional traditional Chinese medicinal anticancer nano-carrier and application thereof
  • Multifunctional traditional Chinese medicinal anticancer nano-carrier and application thereof
  • Multifunctional traditional Chinese medicinal anticancer nano-carrier and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0040] 1. Dissolve 0.3g of ferrocene in 30mL of acetone, add 1.5mL of hydrogen peroxide aqueous solution with a mass concentration of 30% drop by drop after ultrasonic dispersion, and magnetically stir at 1000r / min for 30min to obtain a mixed solution; The mixed solution was transferred to a 40mL autoclave, heated to 210°C under airtight conditions, and reacted for 48 hours after keeping the temperature. After the reaction, it was cooled to room temperature to obtain a black powder; the black powder was washed 3 times with acetone and ethanol, and vacuumed at 40°C. Dry in an oven for 6 hours to obtain carbon-coated superparamagnetic Fe3O4 nanoparticles.

[0041] The carbon-coated superparamagnetic Fe3O4 nanoparticles prepared in step 1 were scanned by electron microscope, and the results are as follows Figure 4 . Figure 4 This is a 200,000 times transmission electron microscope photo of the carbon-coated superparamagnetic Fe3O4 nanoparticles prepared in an embodiment of the pres...

Embodiment 2

[0051] To the acetone solution of dihydroartemisinin, add the multifunctional anti-cancer traditional Chinese medicine nanocarrier of the present invention (coated 15 times), and ultrasonically disperse uniformly to obtain a mixed solution; under stirring, 5 mL of deionized water is added dropwise to the mixed solution, The dropping rate is controlled at 0.1-1mL / min. After the dropping, the reaction is continued to stir at 37°C for 24 hours. The stirring speed is 1000r / min. The acetone volatilizes completely. Wash with deionized water and centrifuge to remove unloaded dihydroartemisinin. Vacuum drying at 40°C for 6 hours to obtain drug-loaded particles.

[0052] The mass ratio of dihydroartemisinin, multifunctional anticancer traditional Chinese medicine nanocarrier and acetone is (0.04-0.1): (0.05-0.1): (7-8).

[0053] Infrared spectroscopy analysis of drug-loaded particles, see results Picture 9 . by Picture 9 It can be seen that 3400cm -1 And 1626cm -1 The peak at indicates t...

Embodiment 3

[0055] To 11.15 mg of dihydroartemisinin and 25 mg of the drug-loaded particles prepared in Example 3, 5 mL of physiological saline was added respectively, and the ultrasonic dispersion was uniform.

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Abstract

The invention discloses a multifunctional traditional Chinese medicinal anticancer nano-carrier and an application thereof, wherein the multifunctional traditional Chinese medicinal anticancer nano-carrier is in the form of carbon-coated superparamagnetic ferroferric oxide nanoparticles covered by an iron-based porous metal organic frame. The iron-based porous metal organic frame has a capacity of efficiently loading dihydroartemisinin; meanwhile, the iron-based porous metal organic frame, which covers the surfaces of the carbon-coated superparamagnetic ferroferric oxide nanoparticles, is degradable in a tumor cell slightly acidic environment, so that ferric ions and the dihydroartemisinin are synchronously released; the ferric ions are further reduced into bivalent ferrous ions by virtue of ferric reductase in cell, and the bivalent ferrous ions are capable of catalyzing the dihydroartemisinin to generate free radicals, so that the tumor cells are killed.

Description

1. Technical Field [0001] The invention relates to a multifunctional anti-cancer Chinese medicine nano carrier and its application, and belongs to the technical field of anti-cancer medicine carriers. 2. Background technology [0002] Cancer is currently one of the biggest disease threats facing humanity. The incidence of cancer has been on the rise in the past 30 years. According to the World Health Organization (WHO) report, China has an average of 2.2 million new cancer cases each year, and the number of deaths due to cancer is about 2.2 million. 1.6 million. In the past 20 years, the cancer mortality rate in China has risen by nearly 30%, ranking first among the causes of death. [0003] Chemotherapy is still one of the main methods of tumor treatment. At present, most of the anti-cancer drugs widely used in clinical practice are still artificially synthesized. These drugs have great toxic side effects while treating cancer. It is an important subject in the field of pharmaco...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K31/366A61P35/00
CPCA61K31/366
Inventor 陈乾旺汪冬冬陈汝慧
Owner UNIV OF SCI & TECH OF CHINA
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