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Application of radix hedysari extract to preparation of product for preventing or treating inflammatory bowel diseases

A technology of inflammatory bowel disease and extract, which is applied in the field of application of Radix Astragali extract in the preparation of products for the prevention or treatment of inflammatory bowel disease, can solve the problems of increased risk of pancreatitis infection, increased risk of lymphoma, etc., to achieve Effects of prevention and treatment of inflammatory bowel disease, simple preparation process steps, and easy large-scale production

Inactive Publication Date: 2020-09-04
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term use of clinical drugs, such as 5-aminosalicylic acid (5-ASA), biologics, and infliximab is limited by toxic side effects, such as increased risk of pancreatitis infection, increased risk of malignancy, and lymphoma

Method used

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  • Application of radix hedysari extract to preparation of product for preventing or treating inflammatory bowel diseases
  • Application of radix hedysari extract to preparation of product for preventing or treating inflammatory bowel diseases
  • Application of radix hedysari extract to preparation of product for preventing or treating inflammatory bowel diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] After the Radix Radix Radix Radix is ​​crushed, 2 times the weight of ethyl acetate is refluxed and extracted 5 times, 1 hour each time. Combine the extracts, remove ethyl acetate by steaming, add diluents commonly used in pharmaceutical preparations, add 60% ethanol to make granules, and pack No. 1 capsules (loading capacity is 0.1g-0.5g) to obtain capsules of the ethyl acetate extract of Radix Astragalus agent.

Embodiment 2

[0029] After the Radix Radix Radix Radix is ​​crushed, 2 times the weight of ethyl acetate is refluxed and extracted 5 times, 1 hour each time. Combine the extracts, evaporate the ethyl acetate, volatilize the remaining Radix Radix Radix to remove the ethyl acetate, then add 6 times the weight of 95% ethanol to the remaining Radix Radix Radix and extract them under reflux for 3 times, 1 hour each time. Combine the extracts, remove ethanol by steaming, add diluents commonly used in pharmaceutical preparations, mix evenly, add 80% ethanol to make granules, pack No. 1 capsules (loading capacity is 0.1g-0.5g), and obtain capsules of the ethanol extract of Radix Astragali .

Embodiment 3

[0031] After the Radix Radix Radix Radix is ​​crushed, 2 times the weight of 95% ethanol is refluxed and extracted 5 times, 1 hour each time. Combine the extracts, remove ethanol by steaming, add common diluents for pharmaceutical preparations, mix evenly, add 95% ethanol to make granules, pack No. 1 capsules (loading capacity is 0.1g-0.5g), and obtain capsules of the total extract of Radix Radix Radix .

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Abstract

The present application provides an application of a radix hedysari extract to the preparation of a product for preventing or treating inflammatory bowel diseases. The radix hedysari extract is a ethyl acetate extract of radix hedysari, an ethanol extract of radix hedysari or a total extract of radix hedysari. The radix hedysari extract contains components such as formononetin, ononin, calycosin,campanulin, isoliquiritigenin, adenosine and medicarpin. The radix hedysari extract provided by the present invention has the effect of treating inflammatory bowel diseases. The radix hedysari extractis simple in preparation process and easy to produce on a large scale.

Description

technical field [0001] The invention relates to the application of the extract of Radix Astragali in the preparation of products for preventing or treating inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease is a chronic, relapsing inflammatory gastrointestinal disorder that can progress to colon cancer. Lesions mainly involve the mucosa and submucosa. Its exact etiology is unknown, and the cause of inflammatory bowel disease is thought to be multifactorial, including genetic predisposition, dysregulated immune responses, epithelial barrier defects, and environmental factors. Because the cause is unknown, inflammatory bowel disease can be difficult to treat. The primary goals of treatment are symptomatic relief and improved quality of life with the long-term goal of prevention of disability, colectomy, and colorectal cancer. The long-term use of clinical drugs, such as 5-aminosalicylic acid (5-ASA), biologics, and infliximab, is limited by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P1/00A61K31/352
CPCA61K31/352A61K36/48A61K2236/33A61K2236/333A61K2236/39A61P1/00
Inventor 赵良功封士兰施根根
Owner LANZHOU UNIVERSITY