Lipid transport protein inhibitor, application thereof and antibacterial drug

A technology of lipid transporter and inhibitor, which can be used in the field of biomedicine to solve problems such as human health threats

Inactive Publication Date: 2020-09-08
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] At present, the abuse of antibiotics has led to more and more serious bacterial resistance problems, posing a huge threat to human health problems, and even the emergence of highly resistant "super bacteria"

Method used

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  • Lipid transport protein inhibitor, application thereof and antibacterial drug
  • Lipid transport protein inhibitor, application thereof and antibacterial drug
  • Lipid transport protein inhibitor, application thereof and antibacterial drug

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Embodiment Construction

[0027] As used herein:

[0028] "Prepared from" is synonymous with "comprising". As used herein, the terms "comprises," "including," "has," "containing," or any other variation thereof, are intended to cover a non-exclusive inclusion. For example, a composition, step, method, article, or device comprising listed elements is not necessarily limited to those elements, but may include other elements not explicitly listed or inherent to such composition, step, method, article, or device. elements.

[0029] The conjunction "consisting of" excludes any unspecified elements, steps or components. If used in a claim, this phrase will make the claim closed so that it does not contain material other than those described except for the customary impurities associated therewith. When the phrase "consisting of" appears in a clause of the subject of a claim rather than immediately following the subject matter, it only defines the elements described in that clause; other elements are not e...

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Abstract

The invention provides a lipid transport protein inhibitor, application thereof and an antibacterial drug. The target of the lipid transport protein inhibitor is located at one or more amino acid sites in a MlaFEDB protein complex; preferably, the target of the lipid transport protein inhibitor is located on at least one of MlaD protein, MlaF protein and MlaE protein. According to the invention, key amino acid sites participating in phospholipid transport in the MlaFEDB protein complex are studied, and it is found that multiple amino acid sites in MlaD protein, MlaE protein and MlaF protein play a key role in phospholipid transport, Once the functions of the amino acids are destroyed, the phospholipid transport efficiency can be remarkably influenced, and then bacterial survival is influenced. Therefore, development of antibacterial drugs by taking the amino acids as targets has very important significance.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a lipid transport protein inhibitor, its application and bacteriostatic drugs. Background technique [0002] At present, the abuse of antibiotics has led to more and more serious problems of bacterial resistance, posing a huge threat to human health problems, and even highly resistant "super bacteria". Among them, Gram-negative bacteria are very difficult to treat. The main reason is that the unique envelope system on the surface of Gram-negative bacteria can prevent the entry of toxic substances and resist the destruction of them by substances such as antibiotics. Studies have shown that the envelope system consists of inner membrane (inner membrane, IM), outer membrane (outer membrane, OM) and soluble periplasm. OM has a unique structure, composed of asymmetrically distributed phospholipids (phospholipids, phospholipids) and lipopolysaccharide (LPS); while the inner membrane (innerm...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/5415A61P31/04
CPCA61K31/5415A61K45/00A61P31/04
Inventor 董浩浩唐晓迪罗庆华
Owner SICHUAN UNIV
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