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Application of procyanidin B2 in preparation of drug for inhibiting pressure-load ventricular remodeling

A proanthocyanidin and ventricular remodeling technology, applied in the field of medicine, can solve the problems of many side effects and poor drug efficacy

Pending Publication Date: 2020-09-11
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Technical problem to be solved: In view of the above technical problems such as poor curative effect and many side effects of pressure load-type ventricular remodeling drugs, one of the purposes of the present invention is to provide the application of proanthocyanidin B2 in the preparation of pressure load-type ventricular remodeling drugs

Method used

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  • Application of procyanidin B2 in preparation of drug for inhibiting pressure-load ventricular remodeling
  • Application of procyanidin B2 in preparation of drug for inhibiting pressure-load ventricular remodeling
  • Application of procyanidin B2 in preparation of drug for inhibiting pressure-load ventricular remodeling

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Embodiment 1

[0029] The structural formula of proanthocyanidin B2 is The procyanidin B2 (Procyanidin B2) MW=578.53.

[0030] The pressure load-inhibiting ventricular remodeling drug also includes one or more pharmaceutically acceptable carriers. The pressure load-inhibiting ventricular remodeling drugs also include pharmaceutically acceptable salts or esters of proanthocyanidin B2, and the pharmaceutically acceptable salts of proanthocyanidin B2 include one of inorganic or organic acid salts, inorganic or organic alkali salts, wherein Inorganic or organic acid salts such as hydrochlorides, hydrobromides, phosphates, sulfates, citrates, lactates, tartrates, maleates, fumarates, mandelates and oxalates; inorganic or Organic base salts such as sodium hydroxide, trishydroxymethylaminomethane and N-methyl-glucosamine, the pharmaceutically acceptable esters of proanthocyanidin B2 include but are not limited to esters with C1-C6 alkyl, C3-C6 straight chain Alkyl or benzyl esters.

[0031] Pro...

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Abstract

The invention discloses application of procyanidin B2 in preparation of a drug for inhibiting pressure-load ventricular remodeling. The drug for inhibiting pressure-load ventricular remodeling also includes pharmaceutically acceptable salt or ester of procyanidin B2, the pharmaceutically acceptable salt of procyanidin B2 includes one of salt of inorganic acid or organic acid and salt of inorganicbase or organic base, the salt of inorganic acid or organic acid comprises hydrochloride, hydrobromide, phosphate, sulfate, citrate, lactate, tartrate, maleate, fumarate, mandelate and oxalate, and the salt of inorganic base or organic base comprises sodium hydroxide, Trismetyl aminomethane and N-methyl-glucosamine; and the pharmaceutically acceptable ester of procyanidin B2 includes but are not limited to alkyl ester of C1-C6, linear alkyl ester of C3-C6 or benzyl ester. The invention provides the application of procyanidin B2 and the pharmaceutically acceptable salt or ester of procyanidin B2 in preparation of the drug for inhibiting pressure-load ventricular remodeling.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of proanthocyanidin B2 in the preparation of pressure load-inhibiting ventricular remodeling drugs. Background technique [0002] Grape seed proanthocyanidin is a natural polyphenolic compound extracted from grape seeds. It is one of the most powerful free radical scavengers found so far. It has strong anti-oxidation, anti-glycosylation activity, and It has a strong cardiovascular protective effect; as a natural plant ingredient, it has no obvious toxic reaction and is widely used at home and abroad. Among them, the dimer is the most widely distributed among various proanthocyanidins and has the strongest antioxidant activity. Grape seed proanthocyanidin B2 is the main component of grape seed proanthocyanidin, and the activity of proanthocyanidin B2 is the strongest among the 8 isomers. [0003] Modern pharmacological studies have shown that proanthocyanidin B...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61P9/00A61K36/87
CPCA61K31/353A61P9/00A61K36/87
Inventor 许晓乐曾翼王霏
Owner NANTONG UNIVERSITY
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