Ultrasound-guided drug-loaded microbubble delivery method and device
A drug-loaded and microbubble technology, applied in the field of ultrasound, can solve the problems of inaccurate delivery of drug-loaded microbubbles, long time-consuming, complicated operation, etc., to achieve better delivery effect, improve accuracy, and avoid tissue damage Effect
Active Publication Date: 2020-10-02
NANJING TRANSCEND VIVOSCOPE BIO TECH CO LTD
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Problems solved by technology
The UTMD system guided by MRI is usually monitored by magnetic resonance thermometry, with a temperature accuracy of 1°C, a spatial resolution of 1mm, and a temporal resolution of 1s, but the equipment is expensive and the operation is complicated.
Although the use of ultrasound imaging for guidance overcomes the problem of high cost of MRI guidance, it requires doctors to operate in the process of imaging monitoring and breaking drug-loaded microbubbles. The delivery effect of drug-loaded microbubbles is affected by human factors, making drug-loaded microbubbles The location of the delivery is not precise enough and takes a long time
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[0040] The following will clearly and completely describe the technical solutions in the embodiments of the application with reference to the drawings in the embodiments of the application. Apparently, the described embodiments are only some, not all, embodiments of the application. Based on the embodiments in this application, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of this application.
[0041] Application overview
[0042] As mentioned above, the current delivery method of drug-loaded microbubbles adopts imaging observation of drug-loaded microbubbles, artificially selects the focus position of breaking, and realizes the control and release of drug-loaded microbubbles each time through people's experience. Since the release position of the drug-loaded microbubbles is artificially set, the error is relatively large. Ultrasound imaging and breaking drug-loaded microbubbles are realized...
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The invention provides an ultrasonic-guided drug-loaded microbubble delivery method and device, electronic equipment and a computer readable storage medium. The method comprises the following steps: sending out a first ultrasonic signal by utilizing an array transducer so as to break drug-loaded microbubbles in a current breaking area; sending out a second ultrasonic signal by using the array transducer to obtain an ultrasonic image; identifying a blood vessel contour of the breaking area according to the ultrasonic image; and updating the characteristic parameters of the breaking area according to the blood vessel contour. According to the invention, since the breaking area is updated in real time according to the blood vessel contour, the breaking accuracy of the drug-loaded microbubblesis improved, and the delivery effect of the drug-loaded microbubbles is better; and the breaking area is kept in a blood vessel all the time by updating the breaking area parameters continuously, sounnecessary tissue damage caused by transmitting ultrasonic signals to tissue around the blood vessel is avoided. Meanwhile, the delivery time of the drug-loaded microbubbles is also shortened.
Description
technical field [0001] The present application relates to the field of ultrasound technology, in particular to an ultrasound-guided drug-loaded microbubble delivery method, device, electronic equipment, and computer-readable storage medium. Background technique [0002] The drug release system is to encapsulate the drug in the carrier and implant or inject it into the body. The drug release is achieved through the slow degradation of the carrier in the body or the induction of exogenous stimuli, and the concentration of the drug in the local lesion tissue is increased. [0003] In recent years, the emergence of Ultrasound-Targeted Microbubble Destruction (UTMD) technology has solved the two challenges of drug targeted delivery and drug penetration into blood vessels and cells, and has attracted more and more attention. . UTMD technology uses ultrasound contrast agents to induce local microflow and shear force under the action of focused ultrasound, stimulate the opening of ...
Claims
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Patent Timeline
Login to View More IPC IPC(8): A61M37/00
CPCA61M37/0092A61B8/481A61B8/0833A61B8/0891A61B8/488A61B8/483A61N2007/0039A61N2007/0052A61K41/0028A61N7/00A61N2007/0095A61N2007/027A61B2034/105A61B8/06
Inventor 郭雯雨安健董飞宏黄硕张珏
Owner NANJING TRANSCEND VIVOSCOPE BIO TECH CO LTD