Composition for skin permeation of macromolecular drugs

Abstract

The present invention provides a composition for transdermally permeating a macromolecular drug wherein the composition comprises an extract of a plant causing a skin inflammatory response, which extract can be used to prepare a composition for transdermally permeating a macromolecular drug, forming a transdermal drug delivery system. The composition can comprise a vasodilator, so as to improve the efficacy of the macromolecular drug penetrating into the blood through the skin.

Description

technical field [0001] The present invention relates to a composition for permeating macromolecular drugs through the skin, in particular to a composition for permeating macromolecular drugs through the skin prepared from extracts of plants that cause skin inflammation. Background technique [0002] The way drugs enter the human body can be roughly divided into three forms: oral administration, injection, and a relatively new transdermal approach, each of which has its importance and applicable timing. Oral medication is currently the most widely used method of administration. Although it is convenient and easy to obtain, many oral medications will first be decomposed in the gastrointestinal digestive system, and then enter the blood circulation system through the first-pass effect of the liver The therapeutic effect is produced, but also because the process is too long and the variables of the digestive system cannot be accurately controlled, the dosage is too large and cau...

AI Technical Summary

Problems solved by technology

The main reason is the barrier properties of the skin, causing the amount of drug to penetrate the skin can not reach the effective concentration of the treatment

In addition, the irritation caused by drugs or carriers to the skin also needs to be carefully considered, especially in the subtropical zone of Taiwan. If the patch is stuck on the skin for too long, it is easy to cause sweating or even allergies. Therefore, the design of transdermal dosage forms still has a lot to do room for improvement

In terms of promotion methods, emerging physical methods are effective and safe, but such methods involve auxiliary equipment, are inconvenient to carry and are expensive, making their application less common than chemical promotion methods. Therefore, how to reduce the size of auxiliary equipment and supply them cheaply Giving patients or consumers is also the focus of future research and development

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