Composition for skin permeation of macromolecular drugs

A technology of macromolecules and compositions, applied in the field of compositions of macromolecular drugs permeable through the skin, can solve the problems of sweating and even allergies, inconvenience in carrying, high price, etc., and achieves increasing skin permeability and promoting blood vessel permeability. , the effect of high controllability

Active Publication Date: 2020-10-09
傅柏舜 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main reason is the barrier properties of the skin, causing the amount of drug to penetrate the skin can not reach the effective concentration of the treatment
In addition, the irritation caused by drugs or carriers to the skin also needs to be carefully considered, especially in the subtropical zone of Taiwan. If the patch is stuck on the skin for too long, it is easy to cause sweating or even allergies. Therefore, the design of transdermal dosage

Method used

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  • Composition for skin permeation of macromolecular drugs
  • Composition for skin permeation of macromolecular drugs
  • Composition for skin permeation of macromolecular drugs

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0036] Preparation Example 1. Biting Dog Extract

[0037] Wash the leaves of the biting dog, chop them up and make juice, add wine (95% ethanol solution) to soak for 1 day at a ratio of 1:1 by volume, and then let it air-dry at room temperature. Dissolve in water according to the required concentration when applying.

preparation example 2

[0038] Preparation example 2. Biting cat extract

[0039] Wash the leaves of the biting cat, chop them up and beat them into juice, add wine (95% ethanol solution) to soak for 1 day at a ratio of 1:1 by volume, and then let them air dry at room temperature. Dissolve in water according to the required concentration when applying.

preparation example 3

[0040] Preparation example 3. aunt taro extract

[0041] Wash the leaves and stems of aunt taro at a ratio of 1:1, chop and make juice, add wine (95% ethanol solution) to soak for 1 day at a ratio of 1:1 by volume, and then let it air-dry at room temperature. Dissolve in water according to the required concentration when applying.

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PUM

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Abstract

The present invention provides a composition for transdermally permeating a macromolecular drug wherein the composition comprises an extract of a plant causing a skin inflammatory response, which extract can be used to prepare a composition for transdermally permeating a macromolecular drug, forming a transdermal drug delivery system. The composition can comprise a vasodilator, so as to improve the efficacy of the macromolecular drug penetrating into the blood through the skin.

Description

technical field [0001] The present invention relates to a composition for permeating macromolecular drugs through the skin, in particular to a composition for permeating macromolecular drugs through the skin prepared from extracts of plants that cause skin inflammation. Background technique [0002] The way drugs enter the human body can be roughly divided into three forms: oral administration, injection, and a relatively new transdermal approach, each of which has its importance and applicable timing. Oral medication is currently the most widely used method of administration. Although it is convenient and easy to obtain, many oral medications will first be decomposed in the gastrointestinal digestive system, and then enter the blood circulation system through the first-pass effect of the liver The therapeutic effect is produced, but also because the process is too long and the variables of the digestive system cannot be accurately controlled, the dosage is too large and cau...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/46A61K47/18A61K38/28A61K38/26A61P3/10
CPCA61K9/0014A61K47/46A61K47/18A61K38/28A61K38/26A61P3/10
Inventor 傅柏舜陈思霈翁伟杰翁伟豪
Owner 傅柏舜
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