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Application of chemotactic factor CX3CL1 in preparation of vaccine and helicobacter pylori vaccine

A Helicobacter pylori and chemokine technology, applied in the field of vaccines, can solve problems such as insufficient recruitment, and achieve the effects of reducing the amount of colonization, reducing the response, and improving immunogenicity

Active Publication Date: 2020-10-09
SECOND MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Today's Helicobacter pylori vaccines also generally have the problem of insufficient local recruitment of effective responses to the gastric mucosa

Method used

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  • Application of chemotactic factor CX3CL1 in preparation of vaccine and helicobacter pylori vaccine
  • Application of chemotactic factor CX3CL1 in preparation of vaccine and helicobacter pylori vaccine
  • Application of chemotactic factor CX3CL1 in preparation of vaccine and helicobacter pylori vaccine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0059] 1. Animal immunization and challenge experiment protocol

[0060] Experimental animals: female BALB / c mice, 6-8 weeks old.

[0061] Grouping: IMPDH, IMPDH+CX3CL1, CSII, CSII+CX3CL1, UreB, UreB+CX3CL1, IMPDH+CSII+UreB, IMPDH+CSII+UreB+CX3CL1. Helicobacter pylori antigen 100μg / head (if Helicobacter pylori antigen contains multiple antigens, each antigen is mixed in equal proportions), CX3CL1 25μg / head, equal amount of PBS control. The amino acid sequence of IMPDH is shown in SEQ ID NO.1; the amino acid sequence of CSII is shown in SEQ ID NO.2; the amino acid sequence of UreB is shown in SEQ ID NO.3; the chemokine CX3CL1 is a purchased commercial product, Recombinant mouse CX3CL1 protein(Active)(ab240868), please refer to https: / / www.abcam.com / recombinant-mouse-cx3cl1-protein-active-ab240868.html.

[0062] Adjuvant: Freund's adjuvant, 100μl / only.

[0063] Immunization method: antigen + Freund's adjuvant, subcutaneous injection. CX3CL1, intraperitoneal injection.

[0064] Immune ...

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Abstract

The invention provides application of a chemotactic factor CX3CL1 in preparation of a vaccine and a helicobacter pylori vaccine, and relates to the technical field of vaccines. Application of the chemotactic factor CX3CL1 in preparation of vaccines is helpful for improving the durability and effectiveness of the vaccines. The helicobacter pylori vaccine provided by the invention comprises a helicobacter pylori antigen and a chemotactic factor CX3CL1, so that the problems of poorer effectiveness and durability of the conventional helicobacter pylori vaccine and insufficient local recruitment ofexcited effective response to gastric mucosa are solved.

Description

Technical field [0001] The invention relates to the technical field of vaccines, in particular to the application of a chemokine CX3CL1 in preparing vaccines and Helicobacter pylori vaccines. Background technique [0002] Helicobacter pylori (H. pylori) is a spiral-shaped gram-negative bacterium that colonizes the gastric mucosa. It can cause gastritis, gastric ulcer, gastric mucosa-associated lymphoid tissue lymphoma (gastric mucosa-associated lymphoid tissue lymphoma, MALT) and even stomach cancer and a series of diseases. The World Health Organization has identified Helicobacter pylori as a Class I carcinogen of gastric cancer in 1994. Epidemiological surveys show that Helicobacter pylori has infected more than half of the world's population, especially in developing countries. [0003] The triple therapy of bismuth and antibiotics is currently the main method for the treatment of Helicobacter pylori infection, but this treatment method has the disadvantages of easily causing ...

Claims

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Application Information

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IPC IPC(8): A61K38/19A61K39/106A61P31/04A61P1/04
CPCA61K38/195A61K39/105A61P31/04A61P1/04A61K2300/00
Inventor 孙合强邓新立蔡力力王科宇龚美亮李玉茹周玉郑青侯传东
Owner SECOND MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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