Drug action target screening method and device based on biological network data, electronic equipment and storage medium

Abstract

The invention relates to a drug action target screening method and device based on biological network data, electronic equipment and a storage medium. The method comprises the following steps: obtaining a plurality of basic diseases and / or symptoms corresponding to complex diseases, retrieving and obtaining a plurality of first biological gene sets, and carrying out union set operation to obtain asecond biological gene set corresponding to the complex diseases; establishing a plurality of background biological network data sets and obtaining first biological network data of the complex disease according to the second biological gene set; obtaining a name list corresponding to the corresponding network data based on a preset drug to obtain third biological network data of the preset drug;obtaining a corresponding relationship between network nodes of the first biological network data and the third biological network data, and establishing a corresponding composite network for an intersection of the first biological network data and the third biological network data according to the obtained directed biological network; acquiring nodes meeting conditions in the composite network toserve as drug action targets of preset drugs. By implementing the method, the accuracy of determining the drug action target can be improved.

Description

technical field [0001] The present invention relates to the technical field of drug action target screening, and more specifically relates to a drug action target screening method, device, electronic equipment and storage medium based on biological network data. Background technique [0002] There are many drugs related to complex diseases, and the candidate target genes of drugs are many and complicated, so rational and effective narrowing of the range is an important problem that needs to be solved urgently. Analyzing from the pathogenesis of complex diseases as an entry point will achieve twice the result with half the effort. In recent years, the emergence of a large number of multi-omics data and the rise of analysis techniques have brought opportunities and challenges to the development of this field. Among them, the analysis at the level of transcriptomics is the starting point and foundation of subsequent proteomics analysis, metabolomics analysis, and metagenomics ...

AI Technical Summary

Problems solved by technology

[0003] Most of the existing protein network-based drug target determination methods or gene-based analysis methods are based on a certain characteristic of complex diseases or a certain molecular pathway of drugs to screen the target, and the conclusions are too one-sided.

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