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Injection microemulsion preparation system and method

A technology for preparing systems and injections, which is applied in the direction of making drugs into special physical or ingestible devices, other household appliances, household components, etc., which can solve the problems of insufficient microemulsion preparation, targeted control of injections, and packaging Problems such as poor transmembrane transport effect

Pending Publication Date: 2020-10-27
SHANGHAI NEW ASIA PHARMA
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AI Technical Summary

Problems solved by technology

[0003] The preparation of microemulsions for flurbiprofen axetil injection is particularly important. The preparation of microemulsions in the prior art is not in place, and its preparation is related to the targeting of injections, and the effect of controlling encapsulation and transmembrane transport is not good

Method used

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  • Injection microemulsion preparation system and method

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Embodiment Construction

[0024] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0025] figure 1 Schematic diagram of the system for the preparation of microemulsions for injection.

[0026] Such as figure 1 As shown, the flurbiprofen axetil injection microemulsion preparation system includes: including oil phase tank, water phase tank, mixing pump, high pressure homogenizer, 1# turnover tank, 2# turnover tank, 3# turnover tank and liquid storage Can.

[0027] The oil phase tank has a built-in stator rotor dispersing and stirring device, and a jacketed container outside, which plays the role of two-phase mixing and homogenization. The water phase tank has a built-in stirring device and a jacketed container for uniform mixing. The high-pressure homogenizer makes the material in the suspension state flow through the cavity with a special internal structure at high speed under the action of ultra-high pressure, and finally...

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Abstract

The invention provides an injection microemulsion preparation system and method. A built-in stirring device is arranged in an oil phase pot and an aqueous phase pot, an outlet of the oil phase pot andan outlet of the aqueous phase pot are connected with an inlet of a mixing pump, an outlet of the mixing pump is connected with an inlet of a high-pressure homogenizing machine, the high-pressure homogenizing machine is provided with a homogenizing first outlet and a homogenizing second outlet, the homogenizing first outlet is connected with an inlet of a 1# turnover pot, an outlet of the 1# turnover pot is connected with an inlet of the oil phase pot and / or the aqueous phase pot, the homogenizing second outlet is connected with an inlet of a 2# turnover pot, an outlet of the 2# turnover potis connected with an inlet of a 3# turnover pot, the 3# turnover pot is provided with a turnover first outlet and a turnover second outlet, the turnover first outlet is connected with an inlet of thehigh-pressure homogenizing machine, and the turnover second outlet is connected with an inlet of a liquid storing pot. The injection microemulsion preparation system and method have the advantages that microemulsion preparation is targeted, and the injection can be guaranteed to achieve the effects of targetting properties, control package and transmembrane transport.

Description

technical field [0001] The invention discloses a microemulsion preparation system and method for injection, in particular to a microemulsion preparation system and method for flurbiprofen axetil injection. Background technique [0002] Flurbiprofen axetil is an antipyretic analgesic and non-steroidal anti-inflammatory drug. Compared with other non-steroidal anti-inflammatory drugs, it is a drug with stronger analgesic effect and less adverse reactions. Intravenous administration of flurbiprofen axetil injection can reduce gastrointestinal complications caused by oral flurbiprofen. However, flurbiprofen axetil injection has the concept of targeted analgesia, preemptive analgesia and comfortable analgesia, which can achieve the following purposes: (1) Targeting, so that the encapsulated drug can be gathered at the lesion to enhance drug efficacy and reduce Drug side effects; (2) control the release of encapsulated drugs, prolonging the duration of drug effects; (3) easy trans...

Claims

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Application Information

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IPC IPC(8): A61J3/00
CPCA61J3/00A61J2200/40
Inventor 商鼎陈龙张晓航赵海峰
Owner SHANGHAI NEW ASIA PHARMA
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