2results about How to "Mild reaction system" patented technology

The present application relates to the technical field of organic synthesis, in particular to a method for synthesizing 2,2'-dithiodi[N-butyl-benzamide] in water phase with ethyl acetate as additive. Sodium iodide and hydroiodic acid are used as key additives to synthesize 2,2'-dithiodi[N-butyl-benzamide], which has certain safety hazards. In view of the above problems, the present application provides a method for synthesizing 2,2'-dithiodi[N-butyl-benzamide] in water phase with ethyl acetate as additive, which is to use 2-butyl-1,2-benzisothiazoline-3-ketone as starting reaction material, sodium sulfide as reducing agent, and ethyl acetate as key additive to synthesize 2,2'-dithiodi[N-butyl-benzamide] in water under room temperature and closed condition. The method of the present application completely avoids the use of strong acid such as hydroiodic acid and sodium iodide. Moreover, the raw materials used are all conventional chemicals, the reaction system is mild, the operation process is safe and reliable, and it is suitable for large-scale production.

This invention discloses a method for synthesizing aggregation-induced emission (AIE) molecules with a carborane skeleton, belonging to the field of organic synthesis. Using 1-iodo-2-methyl-o-carborane as a starting material, alkenyl iodocarborane is obtained in one step via photocatalysis with copper. Subsequently, two Suzuki cross-coupling reactions yield an AIE molecule with a carborane skeleton. The target molecule was then characterized by optical properties, verifying its AIE ability, cell activity, and cell imaging capabilities. This method utilizes readily available raw materials, offers high operational safety, uses inexpensive catalysts, and employs a mild reaction system, providing a practical new route for the large-scale preparation of AIE molecules with a carborane skeleton.