5results about How to "Mild reaction system" patented technology

The present application relates to the technical field of organic synthesis, in particular to a method for synthesizing 2,2'-dithiodi[N-butyl-benzamide] in water phase with ethyl acetate as additive. Sodium iodide and hydroiodic acid are used as key additives to synthesize 2,2'-dithiodi[N-butyl-benzamide], which has certain safety hazards. In view of the above problems, the present application provides a method for synthesizing 2,2'-dithiodi[N-butyl-benzamide] in water phase with ethyl acetate as additive, which is to use 2-butyl-1,2-benzisothiazoline-3-ketone as starting reaction material, sodium sulfide as reducing agent, and ethyl acetate as key additive to synthesize 2,2'-dithiodi[N-butyl-benzamide] in water under room temperature and closed condition. The method of the present application completely avoids the use of strong acid such as hydroiodic acid and sodium iodide. Moreover, the raw materials used are all conventional chemicals, the reaction system is mild, the operation process is safe and reliable, and it is suitable for large-scale production.

The invention provides a brain-targeted neuron ion signal specificity bimodal nanoprobe and a preparation method and application thereof.The nanoprobe comprises mesoporous silicon nanoparticles, and a micromolecular magnetic resonance T1 contrast agent and a potassium ion indicator are loaded in pore channels of the mesoporous silicon nanoparticles; the surfaces of the meso-porous silicon nanoparticles are modified with potassium ion selective filter membranes and brain-targeted ligands. The neuron ion signal specificity fluorescence-magnetic resonance bimodal nanoprobe provided by the invention can effectively combine high-resolution structural magnetic resonance imaging with high-sensitivity functional fluorescence imaging, so that real-time dynamic high-resolution imaging of a neuron potassium ion signal is realized; the method has good research and application prospects in the aspects of precise positioning and operation guidance of the structure-hidden epilepsy focus.

This invention discloses a method for synthesizing aggregation-induced emission (AIE) molecules with a carborane skeleton, belonging to the field of organic synthesis. Using 1-iodo-2-methyl-o-carborane as a starting material, alkenyl iodocarborane is obtained in one step via photocatalysis with copper. Subsequently, two Suzuki cross-coupling reactions yield an AIE molecule with a carborane skeleton. The target molecule was then characterized by optical properties, verifying its AIE ability, cell activity, and cell imaging capabilities. This method utilizes readily available raw materials, offers high operational safety, uses inexpensive catalysts, and employs a mild reaction system, providing a practical new route for the large-scale preparation of AIE molecules with a carborane skeleton.

The invention provides a synthesis method of iodobenzonitrile octanoate, which comprises the following steps: step 1, iodination reaction: in water, mixing p-cyanophenol, an iodination reagent, an acid solution and a catalyst to carry out reaction I, and then dropwise adding hydrogen peroxide to carry out reaction II to obtain 3, 5-diiodine-4-hydroxybenzonitrile; step 2, esterification reaction: dropwise adding an acid-binding agent and capryloyl chloride into a mixed solution of 3, 5-diiodine-4-hydroxybenzonitrile and a solvent, and carrying out reaction III to obtain capryloyl iodobenzonitrile; in the synthesis method, water is used as a reaction solvent during iodination reaction, so that the use of an organic solvent is avoided, the use of the organic solvent is reduced, the synthesis method is environment-friendly, the cost is reduced, a reaction system is mild, and industrial production is easy to realize; in the esterification reaction, an industrial common aromatic solvent benzene is used, is easy to recover and remove water, and can be recycled through simple water washing, liquid separation and water treatment.

The invention relates to a synthesis method of a (tetrahydro) quinoline compound and a (tetrahydro) isoquinoline compound. Specifically, halogenated pyridine and alkyne (alkene) hydrocarbon are prepared under the action of illumination. According to the invention, a series of (tetrahydro) quinoline compounds and (tetrahydro) isoquinoline compounds are obtained from simple and easily available raw materials.