50results about How to "Mild reaction system" patented technology

The method provides a Method for preparation of vitaminA derivant's important intermediate- 1-chloro-2-methyl-4-hydrocarbon acyloxy-2-butylene, this invention adopting isoprene as material to carry through chlorohydrination reaction; the getted product has high content, high produce rate, convenierce operate, little waste and easy to commercial manufacture.

The invention relates to an injectable type alginic acid radical biological material for heart failure adjuvant therapy and a preparation method thereof. The preparation method comprises steps of: preparing two systems of a sodium alginate system and a cross-linking agent system, mixing the two components uniformly by utilizing a three-way syringe and preparing the injectable type alginic acid radical biological material for heart failure / myocardial infarction adjuvant therapy after a proper time of balancing. The materials and processing technologies which are adopted by the invention do not involve organic reagents or organic chemical reactions, the reaction systems are moderate, the conditions are controllable, and the problem of residues of toxic cross-linking agents or auxiliaries cannot be caused; a hydrogel which is prepared according to the technical scheme is injected into the spherical expanding myocardium after heart failure by using the syringe No.271 / 2, so that cardiac ventricles can be helped to reshape, the sizes of the cardiac ventricles can be effectively reduced, and the tension of ventricle walls is decreased; and the biological material can be used for heart failure adjuvant therapy, has good mechanical properties and biological properties as well as good cytocompatibility and is convenient and reliable to operate.

The invention specifically discloses novel gossypol derivatives, and a preparation method and application thereof, belonging to the technical field of organic synthesis. According to the method, gossypol and isonitrile are used as raw materials and undergo a stirring reaction in a polar solvent at 70 to 80 DEG C for 24 and 36 h, then simple filtering and separating are carried out, and thus, a series of the gossypol derivative with modified aldehyde groups are prepared through one-step reaction. The preparation method and post-treatment are simple; a reaction system is mild; and the synthesized novel gossypol derivatives retain all the active phenolic hydroxyl groups unique to gossypol to a greatest extent, and it is estimated that all the excellent biological activities of gossypol are retatined and the problem of toxic aldehyde groups carried by gossypol is overcome. Most of the gossypol derivatives prepared in the invention have good anti-prostatic cancer activity and can be applied in the antineoplastic field.

The invention relates to a cerium oxide / iron oxide / mesoporous silica nano composite material. The surfaces of amino-modified mesoporous silica nanoparticles are respectively modified by ligand-converted cerium oxide nanocrystals and ligand-converted iron oxide nanocrystals. The invention also relates to a preparation method and application of the cerium oxide / iron oxide / mesoporous silica nano composite material. Not only can the composite material carry a drug for treating Alzheimer apostrophe s disease (AD), but also can remove reactive oxide species (ROS) in AD-similar cells, and can be used for diagnosis of the AD as a nuclear magnetic resonance imaging contrast agent, thus realizing integration of diagnosis and treatment of the AD.