Crosslinked alginate-bacterial cellulose sponge and preparation method thereof

Abstract

The invention relates to the field of a biomedical material, and particularly discloses a crosslinked alginate-bacterial cellulose sponge and a preparation method thereof. The crosslinked alginate-bacterial cellulose sponge takes an alginate biomaterial and bacterial cellulose as raw materials. The crosslinked alginate-bacterial cellulose sponge is characterized in that a sponge product is prepared from the alginate biomaterial and the bacterial cellulose in manners of crosslinking and freeze-drying after being compounded, wherein the alginate biomaterial accounts for 80-95% of the sponge product in mass fraction; the bacterial cellulose accounts for 5-20% of the sponge product in mass fraction. The crosslinked alginate-bacterial cellulose sponge is abundant in used material sources, low in cost, controllable to process, and simple in production technology; the prepared crosslinked alginate-bacterial cellulose sponge has good mechanical property, liquid absorption property, water retention capacity and air permeability, and is applicable to bleeding healing of large seepage or a bleeding wound.

Description

(1) Technical field [0001] The invention relates to the field of biomedical materials, in particular to a cross-linked alginic acid-bacterial cellulose sponge and a preparation method thereof. (2) Background technology [0002] With the rapid improvement of social mechanization and the increasingly serious aging problem, the wound care demand gap caused by trauma, disease and other reasons has become increasingly prominent, and the clinical demand for wound care products has become more diversified and high-end. A variety of wound dressing products have been used clinically, such as alginic acid-based dressings, chitosan-based dressings, cellulose-based dressings and other composite dressings, and their product dosage forms also cover sponges, powders, gels, sprays, solutions And other forms to meet different clinical needs. [0003] For wounds with a lot of exudation or bleeding, the water absorption and moisture permeability of traditional dressings still need to be i...

AI Technical Summary

Problems solved by technology

[0006] Relevant patent searches found that Chinese patent CN103041438A discloses a wet antibacterial hydrogel dressing for treating diabetic foot ulcers. The bacterial cellulose hydrogel is combined with calcium alginate hydrogel containing nano-silver to prepare a hydrogel film. It is easy to operate, low in cost, has the properties of sterilization, moisturizing, permeate absorption, and accelerated wound healing. It is suitable for wound healing such as diabetic foot ulcers, venous lower limb ulcers, pressure sores, and donor site wounds. The performance and water absorption performance cannot meet the needs of a lot of exuding or bleeding wounds