NIR-II conjugated nano particles, and preparation method and application thereof

A nanoparticle and near-infrared technology, applied in wave energy or particle radiation treatment materials, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve problems such as limiting large-scale preparation and clinical transformation, and achieve good clinical transformation possibilities. The effect of stability, mild reaction system and stable properties

Active Publication Date: 2019-03-29
ZHEJIANG UNIV
View PDF6 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the potential long-term in vivo toxicity of inorganic materials and the batch-dependent prope

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • NIR-II conjugated nano particles, and preparation method and application thereof
  • NIR-II conjugated nano particles, and preparation method and application thereof
  • NIR-II conjugated nano particles, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0045] Example 1: Conjugated small molecules

[0046] Dibromobenzobisthiadiazole (88.0mg, 0.25mmol), 4-tert-butyl-N-(4-tert-butylphenyl)-N-(4-(5'-trimethylstannyl) -(2,2'-Bithienyl)-5-phenyl)aniline (342.3mg, 0.50mmol) and bis(triphenylphosphine) palladium dichloride (8.77mg, 0.0125mmol) dissolved in 30mL dry toluene Reflux for 24 hours in an inert atmosphere, and finally silica gel column chromatography (eluent is dichloromethane) to obtain near-infrared two-zone conjugated small molecules with a yield of 60%.

[0047] The obtained near-infrared two-region conjugated small molecules were characterized by proton nuclear magnetic resonance spectroscopy and MALDI-TOF mass spectrometry, and the results are as attached figure 1 And figure 2 Shown.

Example Embodiment

[0048] Example 2: Conjugated small molecules

[0049] Dibromobenzobisthiadiazole (88.0mg, 0.25mmol), 4-tert-butyl-N-(4-tert-butylphenyl)-N-(4-(5'-trimethylstannyl) -(2,2'-Bithienyl)-5-phenyl)aniline (342.3mg, 0.50mmol) and tetrakis(triphenylphosphine)palladium (14.4mg, 0.0125mmol) dissolved in 30mL dry toluene, inert Reflux in the atmosphere for 24 hours, and finally silica gel column chromatography (eluent is dichloromethane) to obtain near-infrared two-region conjugated small molecules with a yield of 65%.

Example Embodiment

[0050] Example 3: Conjugated small molecules

[0051] Dibromobenzobisthiadiazole (88.0mg, 0.25mmol), 4-tert-butyl-N-(4-tert-butylphenyl)-N-(4-(5'-trimethylstannyl) -(2,2'-Bithienyl)-5-phenyl)aniline (342.3mg, 0.50mmol) and bis(dibenzylideneacetone)palladium (7.19mg, 0.0125mmol) were dissolved in 30mL of dry toluene, Reflux for 24 hours in an inert atmosphere, and finally silica gel column chromatography (eluent is dichloromethane) to obtain near-infrared two-region conjugated small molecules with a yield of 61%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention relates to NIR-II conjugated nano particles and a preparation method and application thereof. The NIR-II conjugated nano particles comprise NIR-II conjugated small molecules and amphiphilic polymers; a structural formula of the NIR-II conjugated small molecules is as follows; and the amphiphilic polymers are self-assembled and encapsulated on the NIR-II conjugated small molecules. The nanoparticles have good biocompatibility, high NIR-II photothermal conversion efficiency, good photoacoustic imaging effect and NIR-II tumor photothermal therapy effect.

Description

technical field [0001] The invention relates to the field of preparation of conjugated nanoparticles, in particular to a conjugated nanoparticle in the second near-infrared region and its preparation method and application. Background technique [0002] In today's world, malignant tumor has become the number one killer threatening human health. Although traditional treatment methods such as surgery, chemotherapy and radiotherapy have been widely used in clinic, these treatment methods have the disadvantages of invasiveness, large side effects and non-targeting. [0003] In recent years, laser-based photodynamic therapy and photothermal therapy have gained widespread attention due to their advantages of non-invasiveness, minimal side effects, and remote controllability. [0004] At present, photothermal reagents mainly include: noble metal nanomaterials, metal sulfide nanocrystals, carbon materials, two-dimensional materials, and organic nanoparticles. However, the optical ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K41/00A61K9/51A61K47/10A61K47/24A61K49/22A61P35/00
CPCA61K9/5146A61K41/0052A61K49/225A61P35/00
Inventor 凌代舜李方园邵伟
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap