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A kind of cerium oxide/iron oxide/mesoporous silicon nanocomposite material and its preparation method and application

A nano-composite material, iron oxide nano technology, applied in the direction of drug combination, pharmaceutical formula, preparation for in vivo test, etc., can solve the problem of no effective treatment method, no clinical diagnosis specific sign, etc. Good potential for clinical translation, good biocompatibility, and controllable effects

Active Publication Date: 2019-12-17
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In addition to the absence of effective treatments, so far no markers specific for the clinical diagnosis of AD have been identified

Method used

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  • A kind of cerium oxide/iron oxide/mesoporous silicon nanocomposite material and its preparation method and application
  • A kind of cerium oxide/iron oxide/mesoporous silicon nanocomposite material and its preparation method and application
  • A kind of cerium oxide/iron oxide/mesoporous silicon nanocomposite material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Synthesis and ligand conversion of cerium oxide nanocrystals: 0.4 g of cerium acetate hydrate and 3.2 g of oleylamine were added to 15 ml of xylene, stirred at room temperature for 4 hours, and raised to 90 degrees Celsius at a heating rate of 2 degrees Celsius per minute ; Inject 1ml of deionized water into the reaction system protected by an inert gas, age for three hours, precipitate with acetone, and centrifuge to obtain cerium oxide nanocrystals.

[0042] 15 mg of the synthesized cerium oxide nanocrystals, 0.5 g of 2-bromoisobutyric acid and 0.05 g of citric acid were sequentially added to a mixed solvent of 7.5 ml of chloroform and 7.5 ml of N,N-dimethylformamide and stirred for 24 hours. have to.

[0043] X-ray diffraction was performed on the obtained ligand-converted ceria nanocrystals, as shown in the attached figure 1 shown; and the morphology of ligand-converted cerium oxide nanocrystals was characterized by transmission electron microscopy, as shown in...

Embodiment 2

[0052] (1) Synthesis and ligand conversion of cerium oxide nanocrystals: 0.4 g of cerium acetate hydrate and 3.6 g of oleylamine were added to 15 ml of xylene, stirred at room temperature for 6 hours, and raised to 95 degrees Celsius at a heating rate of 2 degrees Celsius per minute ; Inject 1ml of deionized water into the reaction system protected by an inert gas, age for three hours, precipitate with acetone, and centrifuge to obtain cerium oxide nanocrystals.

[0053] 10 mg of the synthesized cerium oxide nanocrystals, 0.5 g of 2-bromoisobutyric acid and 0.05 g of citric acid were sequentially added to a mixed solvent of 7.5 ml of chloroform and 7.5 ml of N,N-dimethylformamide and stirred for 12 hours. have to.

[0054] (2) Synthesis and ligand conversion of iron oxide nanocrystals: 2 g of iron oleate, 1 g of oleic acid, and 2 g of oleyl alcohol were added to 10 g of octadecene. Stir at room temperature, and rise to 300 degrees Celsius at a heating rate of 10 degrees Celsi...

Embodiment 3

[0059] (1) Synthesis and ligand conversion of cerium oxide nanocrystals: 0.4 g of cerium acetate hydrate and 2.8 g of oleylamine were added to 15 ml of xylene, stirred at room temperature for 3 hours, and raised to 85 degrees Celsius at a heating rate of 2 degrees Celsius per minute ; Inject 1ml of deionized water into the reaction system protected by an inert gas, age for three hours, precipitate with acetone, and centrifuge to obtain cerium oxide nanocrystals.

[0060] 20 mg of the synthesized cerium oxide nanocrystals, 0.5 g of 2-bromoisobutyric acid and 0.05 g of citric acid were sequentially added to a mixed solvent of 7.5 ml of chloroform and 7.5 ml of N,N-dimethylformamide and stirred for 4 hours. have to.

[0061] (2) Synthesis and ligand conversion of iron oxide nanocrystals: 2g iron oleate, 1.2g oleic acid, and 2.5g oleyl alcohol were added to 10g octadecene. Stir at room temperature, and rise to 250 degrees Celsius at a heating rate of 10 degrees Celsius per minute...

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Abstract

The invention relates to a cerium oxide / iron oxide / mesoporous silica nano composite material. The surfaces of amino-modified mesoporous silica nanoparticles are respectively modified by ligand-converted cerium oxide nanocrystals and ligand-converted iron oxide nanocrystals. The invention also relates to a preparation method and application of the cerium oxide / iron oxide / mesoporous silica nano composite material. Not only can the composite material carry a drug for treating Alzheimer apostrophe s disease (AD), but also can remove reactive oxide species (ROS) in AD-similar cells, and can be used for diagnosis of the AD as a nuclear magnetic resonance imaging contrast agent, thus realizing integration of diagnosis and treatment of the AD.

Description

technical field [0001] The invention belongs to the field of composite material preparation, and in particular relates to a cerium oxide / iron oxide / mesoporous silicon nanocomposite material and a preparation method and application thereof. Background technique [0002] Alzheimer's disease (Alzheimer's disease, AD), also known as senile dementia, is a neurodegenerative disease caused by impaired language, memory and reasoning of the brain hemispheres, and is the most common disease among the elderly. It is one of the diseases that seriously endanger human health. According to a world epidemiological survey in 2005, there are currently 24.3 million Alzheimer's patients in the world, with 4.6 million new cases each year (one new patient every 7 seconds). And this number will double every 20 years. By 2040, the total number may reach 81.1 million, and most of the patients are concentrated in developing countries. It is predicted that the number of Alzheimer's patients in my co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K47/02A61K47/04A61K45/00A61K49/18A61K49/08A61P25/18
CPCA61K9/5115A61K45/00A61K49/08A61K49/183
Inventor 凌代舜杜阳李方园田梅张宏
Owner ZHEJIANG UNIV
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