Preparing method of cellulose composite sponge

A technology of composite sponge and cellulose, applied in the field of preparation of cellulose composite sponge, can solve problems such as poor compatibility and poor environmental protection, and achieve the effects of mild reaction system, low cost and reduced manufacturing cost

Inactive Publication Date: 2017-09-22
浙江美华鼎昌医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Patent CN101816801 describes a method for preparing medical nasal dressings, but the materials used are artificially synthesized polymer compounds, which have poor compatibility with the human body, and dioxane, a potential carcinogen, is used in the preparation process. Environmental protection is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A preparation method of cellulose composite sponge is characterized in that comprising the steps:

[0029] (1) configure the aqueous solution of 3wt% HPMC and the aqueous solution of 3wt% CMC respectively, and stir to make it dissolve completely;

[0030] (2) Mix the HPMC aqueous solution and the CMC aqueous solution configured in step (1) at a ratio of 1:1, and beat the configured mixed solution evenly through a homogenizer, the temperature is 4°C, and the speed of the homogenizer is 8000rpm, the time is 3 minutes;

[0031] (3) Freeze-dry the uniformly mixed liquid in step (2), freeze at -40°C, and freeze-dry at -50°C for 24 hours;

[0032] (4) Cross-linking the freeze-dried mixture in step (3) in a cross-linking agent for 12 hours, and washing the cross-linked product after cross-linking in the cross-linking agent with pure water;

[0033] (5) The cross-linked product obtained by cross-linking in the cross-linking agent in step (4) is freeze-dried with a freezer to ...

Embodiment 2

[0039] A preparation method of cellulose composite sponge is characterized in that comprising the steps:

[0040] (1) configure the aqueous solution of 3wt% HPMC and the aqueous solution of 3wt% CMC respectively, and stir to make it dissolve completely;

[0041] (2) Mix the HPMC aqueous solution and the CMC aqueous solution configured in step (1) in a ratio of 2:1, and beat the configured mixed solution through a homogenizer at a temperature of 4°C, and the speed of the homogenizer is 8000rpm, the time is 3 minutes;

[0042] (3) Freeze-dry the liquid mixed uniformly in step (2), freeze at -20°C, and freeze-dry at -50°C for 24 hours;

[0043] (4) Cross-linking the freeze-dried mixture in step (3) in a cross-linking agent for 24 hours, and washing the cross-linked product after cross-linking in the cross-linking agent with pure water;

[0044] (5) The cross-linked product obtained by cross-linking in the cross-linking agent in step (4) is freeze-dried with a freezer to obtain ...

Embodiment 3

[0050] A preparation method of cellulose composite sponge is characterized in that comprising the steps:

[0051] (1) configure the aqueous solution of 1wt% HPMC and the aqueous solution of 1wt% CMC respectively, and stir to make it dissolve completely;

[0052] (2) Mix the HPMC aqueous solution and the CMC aqueous solution configured in step (1) at a ratio of 4:1, and beat the configured mixed solution through a homogenizer at a temperature of 4°C, and the speed of the homogenizer is 8000rpm, the time is 3 minutes;

[0053] (3) Freeze-dry the uniformly mixed liquid in step (2), freeze at -40°C, and freeze-dry at -60°C for 24 hours;

[0054] (4) cross-linking the freeze-dried mixture in step (3) in a cross-linking agent, the cross-linking time is 36 hours, and washing the cross-linked product after cross-linking in the cross-linking agent with pure water;

[0055] (5) The cross-linked product obtained by cross-linking in the cross-linking agent in step (4) is freeze-dried wi...

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Abstract

The invention discloses a preparing method of cellulose composite sponge. The preparing method of the cellulose composite sponge comprises the following steps of 1, preparing an aqueous solution of HPMC and an aqueous solution of CMC separately, and conducting even stirring to make the aqueous solution of HPMC and the aqueous solution of CMC fully dissolved; 2, proportionally mixing the aqueous solution of HPMC and the aqueous solution of CMC which are prepared in the step 1, and conducting even mixing; 3, freezing and drying the evenly mixed liquid obtained in the step 2; 4, cross-liking the frozen and dried mixture obtained in the step 3 in a cross-linking agent; 5, using a refrigerator to freeze and dry the cross-linking product cross-linked in the cross-linking agent obtained in the step 4 to obtain a spongy product; 6, packaging and sterilizing the spongy product obtained in the step 5 to obtain the cellulose composite sponge used for hemostasis nursing. According to the preparing method of the cellulose composite sponge, the water absorption and the water binding capacity of the composite material are improved, and the wet strength and flexibility are remarkably improved.

Description

technical field [0001] The invention relates to the field of biomedical materials, and is a degradable porous absorbent material suitable for hemostasis in the nasal cavity of a human body or an animal, in particular to a preparation method of a cellulose composite sponge. Background technique [0002] Nasal packing is the application of fillers to the nasal cavity. The most common purposes of nasal packing are to control bleeding, prevent adhesions or restenosis, and treat epistaxis after septal surgery or rhinoplasty. Packing is also used to support the septum after surgery. [0003] In the case of septoplasty as well as rhinoplasty, the traditional non-degradable packing is usually removed within 24-48 hours, and in the case of epistaxis, the packing is left in place longer to promote healing and prevent patient The packing can remain in the nasal cavity for 7-10 days after touching the wound and accidentally hindering the recovery of the wound. As mentioned above, thes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L1/28C08K5/29
CPCC08L1/284C08L1/286C08L2203/14C08L2205/02C08L2312/00C08K5/29
Inventor 王传跃戴春燕刘丽燕贾昕胡敏均何书麟
Owner 浙江美华鼎昌医药科技有限公司
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