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Ion specific filter membrane/mesoporous silicon composite material, nano sensor, product and application thereof

A composite material and specific technology, applied in the field of ion-specific filter membrane/mesoporous silicon composite material, can solve the problems of narrow fluctuation range, insufficient sensitivity of optical sensor, and achieve controllable conditions, good possibility of clinical transformation, The effect of good biocompatibility

Active Publication Date: 2019-06-14
ZHEJIANG UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

First, during nerve firing, [K + ] o The maximum change of only ten-fold (from 3nM to 30nM, while extracellular Ca 2+ The concentration variation can be as high as 10 4 times); K + Optical sensors are not sensitive enough to detect such a narrow [K + ] o Fluctuation range
Second, although K + The selectivity of the sensor has been significantly improved, but it still cannot distinguish Na + and K +

Method used

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  • Ion specific filter membrane/mesoporous silicon composite material, nano sensor, product and application thereof
  • Ion specific filter membrane/mesoporous silicon composite material, nano sensor, product and application thereof
  • Ion specific filter membrane/mesoporous silicon composite material, nano sensor, product and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0053] (1) Synthesis of mesoporous silica nanoparticles: 2 g of cetyltrimethylammonium chloride and 0.07 g of triethanolamine were sequentially dissolved in 20 ml of deionized water, and heated to 95° C. for 1 h under vigorous stirring. Afterwards, 1.5 ml of ethyl orthosilicate was added dropwise, and the stirring reaction was continued for 1 h. Impurities were removed by washing with methanol several times, and the product was collected by centrifugation. The collected product was extracted with 1 wt% sodium chloride methanol solution for 3 hours to wash away the template agent to obtain mesoporous silica nanoparticles.

[0054] The prepared mesoporous silica nanoparticles were characterized by transmission electron microscopy, as shown in the attached figure 1 As shown, the diameter is about 30-50 nm.

[0055] (2) Synthesis of the composite material of potassium ion-specific filter membrane / mesoporous silicon: 3.4g N-benzyl salicylamide and 2.5g anhydrous potassium carbona...

Embodiment 2

[0061] (1) Synthesis of mesoporous silica nanoparticles: 2 g of cetyltrimethylammonium chloride and 0.07 g of triethanolamine were sequentially dissolved in 20 ml of deionized water, and heated to 95° C. for 1 h under vigorous stirring. Afterwards, 1.5 ml of ethyl orthosilicate was added dropwise, and the stirring reaction was continued for 1 h. Impurities were removed by washing with methanol several times, and the product was collected by centrifugation. The collected product was extracted with 1 wt% sodium chloride methanol solution for 3 hours to wash away the template agent to obtain mesoporous silica nanoparticles.

[0062](2) Synthesis of the composite material of potassium ion-specific filter membrane / mesoporous silicon: 3.4g N-benzyl salicylamide and 2.5g anhydrous potassium carbonate were added successively in 25mL anhydrous dimethylformamide and the temperature was raised to 90 ℃, then added 2.9g 1,1,1-tris(p-toluenesulfonyloxy-methyl)ethane and 0.3mL 2-aminotereph...

Embodiment 3

[0066] (1) Synthesis of mesoporous silica nanoparticles: 2 g of cetyltrimethylammonium chloride and 0.07 g of triethanolamine were sequentially dissolved in 20 ml of deionized water, and heated to 95° C. for 1 h under vigorous stirring. Afterwards, 1.5 ml of ethyl orthosilicate was added dropwise, and the stirring reaction was continued for 1 h. Impurities were removed by washing with methanol several times, and the product was collected by centrifugation. The collected product was extracted with 1 wt% sodium chloride methanol solution for 3 hours to wash away the template agent to obtain mesoporous silica nanoparticles.

[0067] (2) Synthesis of the composite material of potassium ion-specific filter membrane / mesoporous silicon: 3.4g N-benzyl salicylamide and 2.5g anhydrous potassium carbonate were added successively in 25mL anhydrous dimethylformamide and the temperature was raised to 90 ℃, then added 2.9g 1,1,1-tris(p-toluenesulfonyloxy-methyl)ethane and 0.3mL 2-aminoterep...

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Abstract

The invention relates to an ion specific filter membrane / mesoporous silicon composite material, a nano sensor, a product and an application thereof. The ion specific filter membrane / mesoporous siliconcomposite material includes mesoporous silica nanoparticles and an ion specific filter membrane deposited on the surface of the mesoporous silica nanoparticles. The nano sensor comprises the ion specific filter membrane / mesoporous silicon composite material and a corresponding ion indicator adsorbed within the mesoporous silica nanoparticles. The nano sensor can perform dynamical imaging for changes of free-moving in-vivo extracellular ion concentration with high selectivity and high sensitivity, and reflects the brain nerve activity.

Description

technical field [0001] The invention relates to the field of preparation of nanosensors, in particular to a composite material of ion-specific filter membrane / mesoporous silicon, nanosensors, products and applications thereof. Background technique [0002] Techniques that record neuronal activity have long been needed to understand how the brain works. To this end, scientists have actively attempted to construct stretchable electrode arrays for mapping tissue electrophysiology and to design various sensors capable of noninvasively measuring calcium or voltage changes. These advances have opened new avenues for the study of the brain and led to many new biological insights. [0003] K + Is one of the key factors to determine the membrane potential, extracellular K + Concentration ([K + ] o ) changes can directly affect membrane potential and broadly affect neuronal activities, such as activation and inactivation of voltage-gated channels, synaptic transmission, and elect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
Inventor 凌代舜玄泽焕陈忠刘佳男李方园
Owner ZHEJIANG UNIV
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