Preparation method, product and application of inorganic nanoparticle/supramolecular nano targeting compound

Abstract

The invention discloses a preparation method of an inorganic nanoparticle/supramolecular nano targeting compound. The preparation method comprises the following steps: preparing uniform inorganic nanoparticles coated with hydrophobic ligands or cationic ligands; carrying out ligand exchange reaction with a polymer ligand with terminal carboxyl to obtain carboxyl-modified inorganic nanoparticles; carrying out amide condensation reaction on the inorganic nanoparticles and object small molecules with polyamine structures to obtain object molecule modified inorganic nanoparticles; carrying out host-guest interaction with macrocyclic supramolecules as a host to obtain supramolecule modified inorganic nanoparticles; and carrying out host-guest interaction again with a guested targeting ligand toobtain the inorganic nanoparticle/supramolecular nano targeting compound. The invention also discloses the compound obtained by the preparation method and application of the compound in preparation of a biomedical imaging nano contrast agent. According to the compound, targeting ligands are orderly arranged on the surfaces of nanoparticles, and the compound has excellent disease targeting and imaging effects.

Description

technical field [0001] The invention relates to the preparation of targeting nanomaterials, in particular to a preparation method, product and application of an inorganic nanoparticle / supramolecular nano-targeting complex. Background technique [0002] In the 21st century, biomedical imaging technology is one of the important methods for diagnosing diseases. In order to enhance the effect of image observation, researchers have developed and manufactured various contrast agents to improve the contrast of imaging signals between diseased parts and normal tissues, thereby improving the accuracy of diagnosis. In recent years, with the continuous development of nanotechnology, researchers have developed various nano-contrast agents to overcome the potential toxicity of small-molecule contrast agents, short circulation time, and low enrichment of target regions. However, nanocontrast agents developed through existing synthetic strategies have limited their biomedical applications...

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Problems solved by technology

If some literature shows that the connection efficiency of IgG modified on the surface of converted nanoparticles by amide condensation reaction is low, the active site of IgG may directly contact with the surface of nanoparticles, which will affect the biological activity of IgG to a certain extent ( Chem.Commun., 2018, 54, 3851-3854); modifying antibodies on the surface of quantum dots through a bioorthogonal click reaction can control their direction and enhance the targeting effect of quantum dots on tumor cells (Nano Lett.2019, 19 ,1827-1831)

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